Welcome to the Home Page of the Hayashi group in the Department of chemistry, Faculty of Science, Tohoku University.

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Apr. 16. 2014
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Apr. 07. 2014
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Apr. 03. 2014
1st Master course students and 1st Doctor course students entered into our lab.


Jan. 06. 2014
Associate Prof. Martin J. Lear entered into our lab.

Dec. 12. 2013
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Oct. 02. 2013
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Oct. 01. 2013
3rd year undergraduate students entered into our lab.

Sep. 09. 2013
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Sep. 01. 2013
Assistant Professor Kotaro Iwasaki entered into our lab.

Aug. 09. 2013
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Feb. 07. 2013
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Jan. 15. 2013
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Jan. 01. 2013
Lecturer Shuji Yamasahita, and Lecturer Martin J. Lear entered into our lab.


Dec. 03. 2012
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Nov. 17. 2012
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Oct. 29. 2012
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Jul.1.2012
Hayashi lab. has moved.

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Reactions Total Syntheses



                                                                                                                             


  • Asymmetric Aldol Reaction of Formaldehyde Catalyzed by Diarylprolinol

    Chem. Lett., 43, 556-558(2014)
    Yusuke Yasui, Meryem Benohoud, Itaru Sato, and Yujiro Hayashi
    Abstracted in SYNFACTS 2014, 10(4), 0430

  • Solvent-mediated Tuning of the Regioselectivity of Intramolecular Diaryl Ether Formation: Total Synthesis of (+)-Aspercyclide C

    Chem. Lett., 43, 349-351(2014)
    Tatsuya Yoshino, Shuji Yamashita, Itaru Sato, Yujiro Hayashi, and Masahiro Hirama

  • Organocatalyst-Mediated Dehydrogenation of Aldehydes to α,β-Unsaturated Aldehydes, and Oxidative and Enantioselective Reaction of Aldehydes and Nitromethane Catalyzed by Diphenylprolinol Silyl Ether

    Adv. Synth. Catal., 355, 3661-3669 (2013)
    Yujiro Hayashi, Takahiko Itoh, and Hayato Ishikawa
.

  • One-Pot Synthesis of (-)-Oseltamivir and Mechanistic Insights into the Organocatalyzed Michael Reaction

    Chem. Eur. J., 19, 17789-17800 (2013)
    Takasuke Mukaiyama, Hayato Ishikawa, Hiroyuki Koshino ,and Yujiro Hayashi



  • Asymmetric Formal [3 + 2] Cycloaddition Reaction of Succinaldehyde via Diarylprolinol-mediated Domino
    Aldol-Acetalization Reaction for the Construction of Tetrahydrofuran

    Chem. Lett., 42,1294-1296 (2013).
    Yujiro Hayashi, Kentaro Nishino, and Itaru Sato

  • Diarylprolinol in an Asymmetric, Direct Cross-Aldol Reaction with Alkynyl Aldehydes

    ChemCatChem, 5, 2887-2892 (2013)
    Yujiro Hayashi, Masahiro Kojima, Yusuke Yasui, Yuta Kanda, Takasuke Mukaiyama, Hiroki Shomura, Daichi Nakamura,
    Leni Ritmaleni, and Itaru Sato


  • Stoichiometric Reactions of Enamines Derived from Diphenylprolinol Silyl Ethers with Nitro Olefins and Lessons for the Corresponding Organocatalytic Conversions – a Survey

    Helv. Chim. Acta, 96, 799-852 (2013).
    Dieter Seebach, Xiaoyu Sun, Marc-Olivier Ebert, W. Bernd Schweizer, Nirupam Purkayastha, Albert K. Beck, Jörg Duschmalé, Helma Wennemers, Takasuke Mukaiyama, Meryem Benohoud, Yujiro Hayashi and Markus Reiher

  • Asymmetric Mannich Reaction of α-Keto Imines Catalyzed by Diarylprolinol Silyl Ether

    Chem. Eur. J., 19, 7678-7681 (2013)
    Yujiro Hayashi, Daisuke Sakamoto, Hiroki Shomura and Daisuke Hashizume


  • Concise Synthesis of the Tetracyclic Framework of Azadiradione: Tandem Radical Cyclization

    Chem. Lett., 42, 220-221 (2013).
    Shuji Yamashita, Akito Naruko, Takahiro Yamada, Yujiro Hayashi, Masahiro Hirama
  • Organocatalytic 1,4-Addition Reaction of α,β-γ,δ-Diunsaturated Aldehyde versus 1,6-Addition Reaction
    ChemCatChem, 7, 959 (2012).
    Yujiro Hayashi, Daichi Okamura, Shigenobu Umemiya, and Tadafumi Uchimaru
  • Prof. Hayashi was awarded Novartis Chemistry Lectureship.
    Chem. & Eng. News, Sep. 5, 2011.
    Angew. Chem., Int. Ed., 51, 2809 (2012).
       
  • Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile
    Chem. Commun.,48, 4570 (2012).
     
    Yujiro Hayashi, Yusuke Yasui, Masahiro Kojima, Tsuyoshi Kawamura and Hayato Ishikawa

     
      
  • High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (-)-Oseltamivir by Three “One-Pot” Operations
    Most cited paper published in Angew. Chem. Int. Ed. from 2009 to 2010.
    Rank 4th
                               
                                                          
  • One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by a Diphenylprolinol Silyl Ether was selected as a cover picture of Angew. Chem., Int. Ed.
                                                                          
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