N. Mori, T Tachibana, N. Umekubo, Y. Hayashi*
Chem. Sci., 2024, ASAP
DOI: 10.1039/d4sc00193a
Y. Hayashi, E. Cocco, H. Odaira, H. Matoba, N. Mori
Eur. J. Org. Chem. 2024, 27, e202300964
doi/10.1002/ejoc.202300964
| 2024 | |
| 246 | Organocatalyst-mediated asymmetric one-pot/two domino/three-component coupling
reactions for the synthesis of trans-hydrindanes N. Mori, T Tachibana, N. Umekubo, Y. Hayashi* Chem. Sci., 2024, ASAP DOI: 10.1039/d4sc00193a |
| 245 | Oxidative Synthesis of α-Nitroketones from α-Substituted Malononitrile
and Nitrmethane Using Molecular Oxygen without Condensation Reagents Y. Hayashi, E. Cocco, H. Odaira, H. Matoba, N. Mori Eur. J. Org. Chem. 2024, 27, e202300964 doi/10.1002/ejoc.202300964 |
| 2023 | |
| 244 | Organocatalyst Mediated Pot-Economical Total Synthesis of (-)-Quinine and its Derivatives T. Terunuma, G. Kawauchi, Y. Hayashi* Asian. J. Org. Chem. 2023, 12, e202300256 DOI.org/10.1002/ajoc.202300256 Invited paper for the special issue dedicated to Prof. Keiji Maruoka on the occasion of his 70th birthday  |
| 243 | Bis(2-ethylhexyl)amine as an Effective Organocatalyst for the Racemic Reactions
of α,β-Unsaturated Aldehydes Involving an Iminium Ion Y. Hayashi*, X.-L. Han, N. Mori Synlett . 2023, 34(20), 2423-2428 DOI: 10.1055/a-2179-5916 Invited paper for the special issue dedicated to prof. Hisashi Yamamoto on the occasion of his 80th birthday  |
| 242 | Organocatalyst-mediated, pot-economical total synthesis of latanoprost G. Kawauchi, Y. Suga, S. Toda, Y. Hayashi* Chem. Sci. 2023, 14, 10081-10086. DOI:org/10.1039/D3SC02978F  This article was selected as cover picture  |
| 241 | Secondary Amine-Mediated Domino Reaction for the Synthesis of Substituted Quinolines from Dicyanoalkenes and Eneynals Y. Hayashi*, X.-L. Han, N. Mori Chem. Eur. J. 2023, 29, e202301093.. DOI:org/10.1002/chem.202301093  |
| 240 | Diarylprolinol as an Effective Organocatalyst in Asymmetric Cross-aldol Reactions of Two Different Aldehydes Y. Hayashi* Chem. Rec. 2023, 23, e202200159. DOI:org/10.1002/tcr.202200159 |
| 2022 | |
| 239 | Organocatalyst-mediated five-pot synthesis of (-)-quinine T. Terunuma, Y. Hayashi* Nat. Commun. 2022, 13, 7503. DOI:org/10.1038/s41467-022-34916-z   The press release Tohoku Univ. HP https://www.tohoku.ac.jp/japanese/2022/12/press20221208-02-quinine.html Graduate School of Science and Fuculty of Science, Tohoku University HP https://www.sci.tohoku.ac.jp/news/20221208-12401.html https://twitter.com/sci_koho/status/1600673681008885760 |
| 238 | Stereoselective Construction of Fluorinated Quaternary Stereogenic Centers via an Organocatalytic Asymmetric exo-Selective Diels-Alder Reaction in the Presence of Water B. P. Bondzic, K. Daskalakis, T. Taniguchi, K. Monde, Y. Hayashi* Org. Lett. 2022, 24, 7455. DOI.org/10.1021/acs.orglett.2c03043  |
| 237 | Diphenylprolinol Silyl Ether Catalyzed Asymmetric Formal Carbo [3+3]
Cycloaddition Reaction of Isopropylidenemalononitrile and α,β-Unsaturated Aldehyde N. Umekubo, X. Han, N. Mori, Y Hayashi* Eur. J. Org. Chem. 2022, e202200603. DOI:org/10.1002/ejoc.202200603  |
| 236 | Highly Sterically Hindered Peptide Bond Formation between α,α-Disubstituted
α-Amino Acids and N-Alkyl Cysteines Using α,α-Disubstituted α-Amidonitrile X. Wang, J. Li, Y. Hayashi* J. Am. Chem. Soc. 2022, 144, 10145 DOI:org/10.1021/jacs.2c02993 Highlighted in SYNFORM, DOI: 10.1055/s-0040-1720573  |
| 235 | Asymmetric Michael Reaction of Aldehydes and Nitroalkenes Y. Hayashi* Org. Synth. 2022, 99, 68. DOI: 10.15227/orgsyn.099.0068 |
| 234 | Asymmetric Michael reaction of malononitrile and α,β-unsaturated aldehydes catalyzed by diarylprolinol silyl ether Y. Hayashi*, Y. Hatano, N. Mori Synlett 2022, 33, 1831. DOI: 10.1055/a-1846-5007 Invited cluster paper: Development and application of novel ligands/catalysts and mechanistic studies on catalysis Featured in Org. Chem. Highlights   |
| 233 | Asymmetric flow reactions catalyzed by immobilized diphenylprolinol
alkyl ether: Michael reaction and domino reactions Y. Hayashi*, S. Hattori, S. Koshino Chem Asian J. 2022, 17, e202200314. DOI:org/10.1002/asia.202200314  |
| 232 | Diarylprolinol with Trifluoromethyl Substituents and Diphenylprolinol-Derived
Perfluoroalkanesulfonamide as Organocatalysts in the Cross-Aldol Reaction of Aldehydes Y. Hayashi*, M. Tomikawa, N. Mori Adv. Synth. Catal. 2022, 364, 3424. DOI:org/10.1002/adsc.202200266 Invited paper of the special issue dedicated to Prof. Andreas Pfaltz.  |
| 231 | Catalytic Asymmetric Michael Reaction of Methyl Alkynyl Ketone Catalyzed by Diphenylprolinol Silyl Ether N. Umekubo, Y. Hayashi* ACS Org. Inorg. Au 2022, 2, 245. DOI: org/10.1021/acsorginorgau.1c00054  |
| 2021 | |
| 230 | Asymmetric Synthesis of Pentasubstituted Cyclohexanes through Diphenylprolinol Silyl Ether Mediated Domino Michael/Michael Reaction A. S. Odoh, L. Aidanpää, N. Umekubo, H. Matoba, N. Mori, Y. Hayashi* Eur. J. Org. Chem. 2021, 6670. DOI: org/10.1002/ejoc.202101106  |
| 229 | Synthesis of bicyclo[2.2.2]octanes with a quaternary bridgehead carbon by diphenylprolinol silyl ether mediated domino reaction N. Umekubo, T. Taniguchi, K. Monde, Y. Hayashi* Asian. J. Org. Chem. 2021, 10, 3261. DOI: org/10.1002/ajoc.202100573 This manuscript is part of a special collection celebrating the 10th Anniversary of the Asian Jornal of Organic Chemistry.  |
| 228 | Enantiodivergent one-pot synthesis of axially chiral biaryls using
organocatalyst-mediated enantioselective domino reaction and central-to-axial chirality conversion S. Koshino, T. Taniguchi, K. Monde, E. Kwon, Y. Hayashi* Chem. Eur. J. 2021, 27, 15786. DOI: org/10.1002/chem.202102797  |
| 227 | Halogen Bonding of N-Halosuccinimides with Amines and Effects of Brønsted Acids in Quinuclidine-Catalyzed Halocyclizations J. Li, E. Kwon, M. J. Lear, Y. Hayashi* Helv. Chim. Acta. 2021, 104, e210080. DOI: org/10.1002/hlca.202100080 Invited paper of the special issue dedicated to the 75th birthday of Prof. E. P. Kundig.  |
| 226 | Asymmetric synthesis of functionalized 9-methyldecalins using a diphenylprolinol silyl ether-mediated domino Michael/Aldol reaction Y. Hayashi*, H. A. Salazar, S. Koshino Org. Lett. 2021, 23, 6654. DOI: 10.1021/acs.orglett.1c02196  |
| 225 | Three-pot synthesis of chiral anti-1,3-diols through asymmetric organocatalytic
aldol and Wittig reactions followed by epoxidation and reductive opening of the epoxide Y. Hayashi*, M. Tomikawa, N. Mori Org. Lett. 2021, 23, 5896. DOI: 10.1021/acs.orglett.1c01986  |
| 224 | Oxidative peptide bond formation of glycine–amino acid using 2-(aminomethyl)malononitrile as a glycine unit Xiaoling Wang, Jing Li and Yujiro Hayashi* Chem. Commun. 2021, 57, 4283. DOI: 10.1039/D1CC00130B  |
| 223 | Time and Pot Economy in Total Synthesis Yujiro Hayashi Acc. Chem. Res. 2021, 54, 1385. https://doi.org/10.1021/acs.accounts.0c00803  |
| 222 | Amphiphilic Immobilized Diphenylprolinol Alkyl Ether Catalyst on
PS-PEG Resin Seitaro Koshino, Shusuke Hattori, Shota Hasegawa, Naoki Haraguchi, Takeshi Yamamoto, Michinori Suginome, Yasuhiro Uozumi, and Yujiro Hayashi * Bull. Chem. Soc. Jpn. 2021, 94, 790. https://doi.org/10.1246/bcsj.20200355 This article was selected as cover picture and BCSJ award article.    |
| 221 | Direct Cyclopropanation of α‐Cyano β‐Aryl Alkanes by Light‐Mediated Single Electron Transfer Between Donor–Acceptor Pairs Jing Li, Martin J. Lear, Yujiro Hayashi* Chem. Eur. J. 2021, 27, 5901. https://doi.org/10.1002/chem.202100341  |
| 220 | Time Economy in Total Synthesis Yujiro Hayashi* J. Org. Chem. 2021, 86, 1. https://dx.doi.org/10.1021/acs.joc.0c01581   |
| 2020 | |
| 219 | Pot-Economical Total Synthesis of Clinprost Nariyoshi Umekubo and Yujiro Hayashi* Org. Lett. 2020, 22, 9365. https://doi.org/10.1021/acs.orglett.0c03616  |
| 218 | Asymmetric Domino Reaction of α,β-Unsaturated Aldehydes and α-Acyl α,β-Unsaturated
Cyclic Ketones Catalyzed by Diphenylprolinol Silyl Ether Yujiro Hayashi*, Yurina Suga, and Nariyoshi Umekubo Org. Lett. 2020, 22, 8603-8607 https://doi.org/10.1021/acs.orglett.0c03190  |
| 217 | Evidence for an enolate mechanism in the asymmetric Michael reaction of a,b-unsaturated aldehydes and ketones via a hybrid system of two secondary amine catalysts Nariyoshi Umekubo, Takahiro Terunuma, Eunsang Kwon and Yujiro Hayashi Chem. Sci., 2020, 11, 11293-11297 https://doi.org/10.1039/D0SC03359F |
| 216 | Asymmetric synthesis of Corey lactone and latanoprost Nariyoshi Umekubo and Yujiro Hayashi Eur. J. Org. Chem. 2020, 39, 6221-6227 https://doi.org/10.1002/ejoc.202001063 |
| 215 | Asymmetric domino Mukaiyama Michael/Michael reaction catalyzed by
diphenylprolinol silyl ether Nariyoshi Umekubo and Yujiro Hayashi Eur. J. Org. Chem. 2020, 34, 5596-5600 https://doi.org/10.1002/ejoc.202000925 |
| 214 | Highly Enantioselective Access to syn-α,γ-Dihydroxycarbonyl Building
Blocks via Organocatalyst-Mediated Aldol Reaction as a Key Step Xiaoling Wang, Genki Kawauchi, Yujiro Hayashi Chem. Lett. 2020, 49, 940-943 https://doi.org/10.1246/cl.200304  |
| 213 | One-pot synthesis of chiral cis-hydrindanes via diphenylprolinol
silyl ether mediated domino reaction and aldol condensation Nariyoshi Umekubo, Ryohei Iwata, Yujiro Hayashi Chem. Lett. 2020, 49, 867-869 https://doi.org/10.1246/cl.200297  |
| 212 | Asymmetric Michael reaction of aldehydes and α‐cyano α,β‐unsaturated
esters catalyzed by diphenylprolinol silyl ether; a facile asymmetric route
to 3,4,5‐trisubstituted piperidines Yujiro Hayashi, Amaechi Shedrack Odoh, Nektarious Kranidiotis-Hisatomi ChemCatChem, 2020, 12, 2412-2415 https://doi.org/10.1002/cctc.202000113 This publication is part of a Special Collection on “The Catalysis of RingSynthesis”.   |
| 211 | Inversion of the axial information during oxidative aromatization
in the synthesis of axially chiral biaryls using organocatalyst as a key
step Seitaro Koshino, Akira Takikawa, Keiichi Ishida, Tohru Taniguchi, Kenji Monde, Eunsang Kwon, Shigenobu Umemiya, Yujiro Hayashi Chem. Eur. J. 2020, 26, 4524-4530 10.1002/chem.201905814 This article was selected as cover picture and cover profile.   Cover Profile |
| 210 | Pot and time economies in the total synthesis of Corey lactone Nariyoshi Umekubo, Yurina Suga, and Yujiro Hayashi Chem. Sci., 2020, 11, 1205-1209. 10.1039/C9SC05824A This article was selected as cover picture and highlighted in OPR&D.    |
|
2019 |
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| 209 | Diarylprolinol‐Mediated Asymmetric Direct Cross‐Aldol Reaction of α,β‐Unsaturated
Aldehyde as an Electrophilic Aldehyde Prof. Dr. Yujiro Hayashi (林雄二郎) Kaito Nagai (永井海人) Dr. Shigenobu Umemiya (梅宮茂伸) Chem. Asian. J. 2019, 14, 4146-4149. https://doi.org/10.1002/asia.201901236 Special issue for the 100th Annual Meeting of the Chemical Society of Japan  |
| 208 | Asymmetric synthesis of biaryl atropisomers using an organocatalyst‐mediated domino reaction as a key step Y. Hayashi, A. Takikawa, S. Koshino, K. Ishida Chem. Eur. J. 2019, 25, 10319–10322. https://doi.org/10.1002/chem.201902767  |
| 207 | Asymmetric Michael Reaction of α-CF3 Thioester and α,β-Unsaturated Aldehyde Catalyzed by Diphenylprolinol Silyl Ether Y. Hayashi, T. Yamada, M. Sato, S. Watanabe, E. Kwon, K. Iwasaki, S. Umemiya Org. Lett. 2019 ,21, 5183–5186. https://doi.org/10.1021/acs.orglett.9b01774  |
| 206 | Asymmetric Synthesis of Chiral 1,3-Dimethyl Units Through a Double Michael Reaction of Nitromethane and Crotonaldehyde Catalyzed by Diphenylprolinol Silyl Ether Yujiro Hayashi, Shunsuke Toda Synlett, 2019, 30(04), 442-448 DOI: 10.1055/s-0037-1611644 Invited paper to the “30 years SYNLETT Pearl Anniversary Issue”  |
| 205 | Domino Michael/Michael Reaction for the Formation of Chiral Spirocycles
Using a Diphenylprolinol Silyl Ether, Y. Hayashi, K. Nagai, S. Umemiya, Eur. J. Org. Chem., 2019(4), 678-681. DOI: 10.1002/ejoc.201801202.  |
| 204 | Sterically Congested Ester Formation from α‐Substituted Malononitrile and
Alcohol by an Oxidative Method Using Molecular Oxygen Yujiro Hayashi, Jing Li, Hirotaka Asano, Daisuke Sakamoto Eur. J. Org. Chem., 2019, 2019(4), 675-677 https://doi.org/10.1002/ejoc.201800984  |
| 2018 | |
| 203 | Asymmetric Michael Reaction of Aldehydes and Dicyanoalkenes Catalyzed by
Diphenylprolinol Silyl Ether Yujiro Hayashi, Nektarios Kranidiotis‐Hisatomi, Daisuke Sakamoto, Kyohei Oritani, Takuji Kawamoto, Akio Kamimura Eur. J. Org. Chem., 2018, 2018(48), 6843-6847 https://doi.org/10.1002/ejoc.201800831  Selected as a Cover Picture https://doi.org/10.1002/ejoc.201801418  |
| 202 | Domino Michael/Michael Reaction for the Formation of Chiral Spirocycles
Using a Diphenylprolinol Silyl Ether Yujiro Hayashi, Kaito Nagai, Shigenobu Umemiya Eur. J. Org. Chem., 2019, 678-681 https://doi.org/10.1002/ejoc.201801202  |
| 201 | Total Synthesis of Estradiol Methyl Ether and Its Five‐Pot Synthesis with an Organocatalyst Seitaro Koshino, Eunsang Kwon, Yujiro Hayashi Eur. J. Org. Chem., 2018, 41, 5629-5638 DOI: 10.1002/ejoc.201800910 Selected as Cover Picture https://doi.org/10.1002/ejoc.201801580   |
| 200 | Autoinductive conversion of α,α-diiodonitroalkanes to amides and esters
catalysed by iodine byproducts under O2 Jing Li, Martin J. Lear and Yujiro Hayashi Chem. Commun., 2018,54, 6360-6363 DOI: 10.1039/C8CC03191F  |
| 199 | Asymmetric Michael Reaction of Aldehyde and β-Substituted α-Nitroacrylate Catalyzed by Diphenylprolinol Silyl Ether Daisuke Sakamoto and Yujiro Hayashi Chem. Lett., 2018, 47(7), 833-835 DOI: 10.1246/cl.180273 Selected as the Editor's Choice  |
| 198 | Prolinate Salt as a Catalyst in the syn-Selective, Asymmetric Mannich Reaction of Alkynyl Imine Yujiro Hayashi, Tatsuya Yamazaki, Genki Kawauchi, and Itaru Sato Org. Lett., 2018, 20 (8), pp 2391–2394 DOI: 10.1021/acs.orglett.8b00728  |
| 197 | Enantio‐and Diastereoselective Synthesis of Latanoprost using an Organocatalyst Genki Kawauchi, Shigenobu Umemiya, Tohru Taniguchi, Kenji Monde, Yujiro Hayashi Chem. Eur. J., 2018, 24(33), 8409-8414 DOI: 10.1002/chem.201800829  |
| 196 | Two-pot synthesis of chiral 1,3-syn-diols through asymmetric organocatalytic aldol and Wittig reactions, followed by domino hemiacetal/oxy-Michael reactions Yujiro Hayashi, Takanobu Saitoh, Hiromu Arase, Genki Kawauchi, Naohiro Takeda, Yasuharu Shimasaki, and Itaru Sato Chem. Eur. J., 2018, 24(19), 4909-4915 DOI: 10.1002/chem.201705930 |
| 195 | Direct Asymmetric Michael Reaction of α,β-Unsaturated Aldehydes and Ketones
Catalyzed by Two Secondary Amine Catalysts Yujiro Hayashi and Nariyoshi Umekubo Angew. Chem. Int. Ed. 2018, 57, 1958–1962 DOI: 10.1002/anie.201710085 Selected as inside back cover !  |
| 2017 | |
| 194 | Asymmetric Michael Reaction of Aldehydes and Nitroalkenes Yujiro Hayashi and Shin Ogasawara Org. Synth. 2017, 94, 252-258 DOI: 10.15227/orgsyn.094.0252 |
| 193 | Prolinate Salts as Catalysts for α-Aminoxylation of Aldehyde and Associated Mechanistic Insights Yujiro Hayashi* , Nariyoshi Umekubo, and Taku Hirama Org. Lett., 2017, 19, 4155–4158 DOI: 10.1021/acs.orglett.7b01433 |
| 192 | Pot-economical total synthesis of estradiol methyl ether through the use
of an organocatalyst Yujiro Hayashi, Seitaro Koshino, Kanna Ojima and Eunsang Kwon Angew. Chem. Int. Ed. 2017, 56, 11812-11815 DOI: 10.1002/anie.201706046 |
| 191 | Enantioselective Total Synthesis of Beraprost Using Organocatalyst Shigenobu Umemiya, Daisuke Sakamoto, Genki Kawauchi, and Yujiro Hayashi Org. Lett., 2017, 19, 1112–1115 DOI: 10.1021/acs.orglett.7b00134 |
| 190 | Multistep Continuous-Flow Synthesis of (–)-Oseltamivir Ogasawara, Shin; Hayashi, Yujiro: Synthesis, 2017, 49, 424-428. DOI: 10.1055/s-2016-0036-1588899 |
| 2016 | |
| 189 | Time Economical Total Synthesis of (-)-Oseltamivir Yujiro Hayashi and Shin Ogasawara Org. Lett., 2016, 18 (14), pp 3426–3429 DOI: 10.1021/acs.orglett.6b01595 |
| 188 | Enantioselective Total Synthesis of RQN-18690A (18-Deoxyherboxidiene) Yasunobu Matsumoto, Kazuhiro Hibino, Masahiro Yonaga, Hideaki Kakeya, and Yujiro Hayashi Org. Lett., 2016, 18, 3382-3385 DOI: 10.1021/acs.orglett.6b01524 |
| 187 | Asymmetric Aldol Reaction of Dichloroacetaldehyde Catalyzed by Diarylprolinol Yujiro Hayashi, Daichi Nakamura, Yusuke Yasui, Kotaro Iwasaki andHiroaki Chiba Adv. Synth. Catal., 2016, 358, 2345-2351 DOI: 10.1002/adsc.201501111 |
| 186 | Sterically Demanding Oxidative Amidation of a-SubstitutedMalononitriles with Amines Using O2 Jing Li, Dr. Martin J. Lear, Prof. Dr. Yujiro Hayashi Angew. Chem. Int. Ed. 2016, 55, 9060-9064 10.1002/anie.201603399 |
| 185 | The DFT Calculation with NBO Analysis of E/Z Enamines Derived from a-Alkoxyaldehyde with Pyrrolidine T. Mukaiyama, T. Uchimaru, Y. Hayashi Bull. Chem. Soc. Jpn, 2016, 89, 455-459, DOI: 10.1246/bcsj.20150382 |
| 184 | 16O/18O Exchange of Aldehydes and Ketones caused by H218O in the Mechanistic Investigation of Organocatalyzed Michael, Mannich, and Aldol Reactions Prof. Dr. Yujiro Hayashi, Dr. Takasuke Mukaiyama, Dr. Meryem Benohoud, Dr. Nishant R. Gupta, Tsuyoshi Ono and Shunsuke Toda Chem. Eur. J., 2016, 22, 5868-5872, DOI: 10.1002/chem.201600280. |
| 183 | Mechanism of Oxidative Amidation of Nitroalkanes with Oxygen and Amine Nucleophiles by Using Electrophilic Iodine Jing Li, Dr. Martin J. Lear, Prof. Dr. Eunsang Kwon, Prof. Dr. Yujiro Hayashi Chem. Eur. J., 2016, 22, 5538-5542, DOI: 10.1002/chem.201600540. |
| 182 | Total Synthesis of 7,10-Epimer of the Proposed Structure ofAmphidinolide N, Part II: Synthesis of C17-C29 Subunit and Completion of the Synthesis Koji Ochiai,Sankar Kuppusamy,Yusuke Yasui,Kenji Harada Nishant R. Gupta,Yohei Takahashi,Takaaki Kubota,Jun’ichi Kobayashi,and Yujiro Hayashi Chem. Eur. J., 2016, 22, 3287-3291,. DOI: 10.1002/chem.201504675. |
| 181 | Total Synthesis of 7,10-Epimer of the Proposed Structure ofAmphidinolide N, Part I: Synthesis of the C1-C13 Subunit Koji Ochiai,Sankar Kuppusamy,Yusuke Yasui,Tsubasa Okano,Yasunobu Matsumoto,Nishant R. Gupta,Yohei Takahashi,Takaaki Kubota,Jun’ichi Kobayashi,andYujiro Hayashi Chem. Eur. J., 2016, 22, 3282-3286 DOI: 10.1002/chem.201504674. |
| 180 | Total synthesis of avermectin B1a revisited KS. Yamashita, D. Hayashi, A. Nakao, Y. Hayashi, M. Hirama, J. Antibio., 2016, 69, 31-50 DOI: 10.1038/ja.2015.47. |
| 179 | Pot economy and one-pot synthesis Yujiro Hayashi, Chem. Sci., 2016, 7, 866-880, DOI: 10.1039/C5SC02913A. |
| 178 | One-Pot Synthesis of (S)-Baclofen via Aldol Condensation of Acetaldehyde with Diphenylprolinol Silyl Ether Mediated Asymmetric Michael Reaction as a Key Step Yujiro Hayashi, Daisuke Sakamoto, and Daichi Okamura Org.Lett., 2016, 18, 4-7, DOI: 10.1021/acs.orglett.5b02839. |
| 177 | Formal Synthesis of Ezetimibe Using a Proline-mediated, Asymmetric, Three-component Mannich Reaction Yasuharu Shimasaki, Seitaro Koshino, and Yujiro Hayashi Chem.Lett., 2016, 45, 30-32, DOI: 10.1246/cl.150916. |
| 2015 | |
| 176 | Oxidative Amidation of Nitroalkanes with Amine Nucleophiles using Molecular Oxygen and Iodine, Jing Li,Prof. Dr. Martin J. Lear,Yuya Kawamoto,Dr. Shigenobu Umemiya,Alice R. Wong,Prof. Dr. Eunsang Kwon, Prof. Dr. Itaru Sato,Prof. Dr. Yujiro Hayashi, Angew. Chem. Int. Ed., 2015, 54,12986 –12990, DOI: 10.1002/anie.201505192. |
| 175 | Asymmetric Aldol Reaction of Chloral Catalyzed by Diarylprolinol Y. Hayashi, S. Watanabe, Y. Yasui, S. Umemiya ChemCatChem, 2015, 7, 1646-1649, DOI: 10.1002/cctc.201500282. |
| 174 | Asymmetric nitrocyclopropanation of a-substituted a,b-enals catalyzed by diphenylprolinol silyl ether for the construction of all-carbon quaternary stereogenic centers Y. Hayashi, T. Yamazaki, Y. Nakanishi, T. Ono, T. Taniguchi, K. Monde, T. Uchimaru Eur. J. Org. Chem. 2015, 26, 5747-5754 DOI:10.1002/ejoc.201500838. |
| 173 | Two reaction mechanisms via iminium ion intermediates: The different reactivity between diphenylprolinol silyl ether and trifluoromethyl-substituted diarylprolinol silyl ether, H. Gotoh, T. Uchimaru, Y. Hayashi, Chem. Eur. J. , 21,12337-12346,DOI: 10.1002/chem.20150326. Selected “Hot Paper” |
| 172 | Asymmetric Formal [3+2] Cycloaddition Reaction of Succinaldehyde and Nitroalkene Catalyzed by Diphenylprolinol Silyl Ether, S. Umemiya, Y. Hayashi, Eur. J. Org. Chem. 2015, 20, 4320-4324 DOI:10.1002/ejoc.20150623. |
| 171 | Asymmetric Aldol Reaction of α,α-Disubstituted Acetaldehydes Catalyzed by Diphenylprolinol Silyl Ether for the Construction of Quaternary Stereogenic Centers, Y. Hayashi, H. Shomura, Q. Xu, M. J. Lear, I. Sato, Eur. J. Org. Chem. 2015, 20, 4316-4319 DOI:10.1002/ejoc.20150585. |
| 170 | Total Synthesis of Limonin, S. Yamashita, A. Naruko, Y. Nakazawa, L. Zhao, Y. Hayashi, M. Hirama, Angew. Chem. Int. Ed., 2015, , 54, 8538 –8541, DOI: 10.1002/anie.20153794. |
| 169 | Asymmetric Organocatalyzed Epoxidation of 2-Oxoindoline-3-ylidene Acetaldehydes T. Mukaiyama, K. Ogata, T. Ono, Y. Hayashi ChemCatChem., 2015, 7, 155-159, DOI: 10.1002/cctc.201402811. |
| 168 | Practical Route to the Left Wing of CTX1B and Total Syntheses of CTX1B and 54-deoxyCTX1B S. Yamashita, K. Takeuchi, T. Koyama, M. Inoue, Y. Hayashi, M. Hirama, Chem. Eur. J., 2015, 21, 2621-2328, DOI: 10.1002/chem.201405629. |
| 2014 | |
| 167 | The Asymmetric Catalytic Mannich Reaction Catalyzed by Organocatalyst–A Personal Account–, Yujiro Hayashi, J. Synth. Org. Chem., Jpn., 2014, 72, 1228-1238. |
| 166 | Biomimetic Total Synthesis of Cyanosporaside Aglycons from a Single Enediyne Precursor through Site-Selective p-Benzyne Hydrochlorination, K. Yamada, M. J. Lear, T. Yamaguchi, S. Yamashita, I. D. Gridnev, Y. Hayashi, M. Hirama, Angew. Chem. Int. Ed., 2014, 53, 13902-13906, DOI: 10.1002/anie.201408416. |
| 165 | Asymmetric Aldol Reaction of a-Acetoxyimino Aldehydes and its Application in the Synthesis of Substituted 1,2-Oxazine Derivatives Y. Yasui, K. Ogata, I. Sato, Y. Hayashi, Adv. Synth. Catal., 2014, 356, 3106–3118, DOI: 10.1002/adsc.201400294. |
| 164 | Asymmetric Organocatalyzed Michael Addition of Nitrometane to 2-Oxoindoline-3-ylidene acetaldehyde and Three “One-pot” Sequential Synthesis of (–)-Horsfiline and (–)-Coerulescine T. Mukaiyama, K. Ogata, I. Sato, Y. Hayashi, Chem. Eur. J., 2014, 20, 13583-13588, DOI: 10.1002/chem.201403932. Inside cover picture. |
| 163 | Asymmetric Aldol Reaction of a-Acetoxyimino Aldehydes and its Application in the Synthesis of Substituted 1,2-Oxazine Derivatives Y. Yasui, K. Ogata, I. Sato, Y. Hayashi, Adv. Synth. Catal., 2014, 356, 3106–3118, DOI: 10.1002/adsc.201400294. |
| 162 | Asymmetric Organocatalyzed Epoxidation of 2-Oxoindoline-3-ylidene Acetaldehydes Takasuke Mukaiyama, Kento Ogata, Tsuyoshi Ono,and Yujiro Hayashi ChemCatChem, 2014, 7, 155-159 (2014) |
| 161 | Nef reaction with molecular oxygen in absence of metal additives and its mechanistic insight S. Umemiya, K. Nishino, I. Satoh, Y. Hayashi Chem. Eur. J., 2014, 20, 15753-15759 (2014) Hot Paper Inside cover picture. |
| 160 | Asymmetric Organocatalyzed Michael Addition of Nitrometane to 2-Oxoindoline-3-ylidene acetaldehyde and Three “One-pot” Sequential Synthesis of (-)-Horsfiline and (-)-Coerulescine T. Mukaiyama, K. Ogata, I. Sato, Y. Hayashi Chem. Eur. J., 2014, 20, 13583-13588 (2014) |
| 159 | A Theoretical and Experimental Study of the Effects of Silyl Substituents in Enantioselective Reactions Catalyzed by Diphenylprolinol Silyl Ether Y. Hayashi, D. Okamura, T. Yamazaki, Y. Ameda, H. Gotoh, S. Tsuzuki, T. Uchimaru, D. Seebach Chem. Eur. J., 2014, 20, 17077-88(2014),DOI: 10.1002/chem.201403514. |
| 158 | Diphenylprolinol Silyl Ether Catalyzed Asymmetric Michael Reaction of Nitroalkanes and β,β-Disubstituted α,β-Unsaturated Aldehydes for the Construction of All-Carbon Quaternary Stereogenic Centers Y. Hayashi, Y. Kawamoto, M. Honada, D. Okamura, S. Umemiya, Y. Noguchi, T. Mukaiyama, and I. Sato Chem. Eur. J., 2014, 38, 12072-12082 (2014) |
| 157 | Asymmetric Aldol Reaction of Formaldehyde Catalyzed by Diarylprolinol Y. Yasui, M. Benohoud, Itaru. Sato, and Y. Hayashi Chem. Lett., 2014, 43, 556-558 (2014) Abstracted in SYNFACTS 2014, 10(4), 0430 |
| 156 | Solvent-mediated Tuning of the Regioselectivity of Intramolecular Diaryl Ether Formation: Total Synthesis of (+)-Aspercyclide C T. Yoshino, S. Yamashita, I. Sato, Y. Hayashi, and M. Hirama Chem. Lett., 2014, 43, 349-351 (2014) |
| 2013 | |
| 155 | Organocatalyst-Mediated Dehydrogenation of Aldehydes to α,β-Unsaturated Aldehydes, and Oxidative and Enantioselective Reaction of Aldehydes and Nitromethane Catalyzed by Diphenylprolinol Silyl Ether Y. Hayashi, T. Itoh, and H. Ishikawa Adv. Synth. Catal., 18, 3661-3669 (2013) |
| 154 | One-Pot Synthesis of (-)-Oseltamivir and Mechanistic Insights into the Organocatalyzed Michael Reaction T. Mukaiyama, H. Ishikawa H. Koshino, and Y. Hayashi Chem. Eur. J., 52, 17789-17800 (2013) |
| 153 | Remote 1,6-Stereocontrol by Iminium-mediated Organocatalytic Events M. J. Lear, and Y. Hayashi ChemCatChem, 5, 3499-3501 (2013) |
| 152 | Asymmetric Formal [3 + 2] Cycloaddition Reaction of Succinaldehyde via Diarylprolinol-mediated Domino Aldol–Acetalization Reaction for the Construction of Tetrahydrofuran Y. Hayashi, K. Nishino, and I. Sato Chem. Lett, 42,1294-1296 (2013) |
| 151 | Diarylprolinol in an Asymmetric, Direct Cross-Aldol Reaction with Alkynyl Aldehydes Y. Hayashi, M. Kojima, Y. Yasui, Y. Kanda, T. Mukaiyama, H. Shomura, D. Nakamura, L. Ritmaleni, and I. Sato ChemCatChem, 5, 2887-2892 (2013). |
| 150 | Asymmetric Aldol Reaction of Glyoxal Catalyzed by Diarylprolinol Y. Hayashi, and M. Kojima ChemCatChem, 5, 2883-2885 (2013). |
| 149 | Stoichiometric Reactions of Enamines Derived from Diphenylprolinol Silyl Ethers with Nitro Olefins and Lessons for the Corresponding Organocatalytic Conversions – a Survey Dieter Seebach, Xiaoyu Sun, Marc-Olivier Ebert, W. Bernd Schweizer, Nirupam Purkayastha, Albert K. Beck, Jörg Duschmalé, Helma Wennemers, Takasuke Mukaiyama, Meryem Benohoud, Yujiro Hayashi and Markus Reiher Helv. Chim. Acta, 96,799-852 (2013). |
| 148 | Asymmetric Mannich Reaction of α-Keto Imines Catalyzed by Diarylprolinol Silyl Ether Y. Hayashi, D. Sakamoto, H. Shomura and D. Hashizume Chem. Eur. J., 19,7678-7681 (2013) |
| 147 | Pot Economy in the Synthesis of Prostaglandin A1 and E1 Methyl Esters Y. Hayashi, and S. Umemiya Angew. Chem., Int. Ed., 52,3450-3452 (2013). |
| 146 | Concise Synthesis of the Tetracyclic Framework of Azadiradione: Tandem Radical Cyclization S. Yamashita, A. Naruko, T. Yamada, Y. Hayashi, and M. Hirama Chem. Lett., 42, 220-221 (2013). |
| 145 | Stereoselective synthesis of zoanthenol ABC-ring by radical strategy S. Yamashita, N. Suda, Y. Hayashi, and M. Hirama Tetrahedron Letters, 54, 1389 (2013). |
| 144 | Remote C-H bond functionalization of androstane C-ring: C12-amination S. Yamashita, M. Himuro, Y. Hayashi, and M. Hirama Tetrahedron Letters, 54, 1307 (2013). |
| 2012 | |
| 143 | Organocatalytic 1,4-Addition Reaction of α,β-γ,δ-Diunsaturated Aldehyde versus 1,6-Addition Reaction Y. Hayashi, D. Okamura, S. Umemiya, and T. Uchimaru ChemCatChem 4, 959 (2012). |
| 142 | Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile Y. Hayashi, Y. Yasui, M. Kojima, T. Kawamura and H. Ishikawa Chem. Commun., 48, 4570 (2012). |
| 2011 | |
| 141 | Organocatalytic, Enantioselective Intramolecular [6 + 2] Cycloaddition Reaction for the Formation of Tricyclopentanoids and Insight on Its Mechanism from a Computational Study Y. Hayashi, H. Gotoh, M. Honma, K. Sankar, I. Kumar, H. Ishikawa, K. Konno, H. Yui, S. Tsuzuki, and T. Uchimaru J. Am. Chem. Soc., 133, 20175 (2011). |
| 140 | Synthesis of (-)-Oseltamivir by Using a Microreactor in the Curtius Rearrangement H. Ishikawa, Bojan P. Bondzic and Y. Hayashi Eur. J. Org. Chem., 6020 (2011). |
| 139 | One-Pot Synthesis of Chiral Aziridines by a Domino Reaction by Using Desulfonylative Formation on the N-Tosyl Imine of Chloroacetaldehyde with an Asymmetric Mannich Reaction as a Key step Y. Hayashi, T. Urushima, D. Sakamoto, K. Torii and H. Ishikawa Chem. Eur. J., 17, 11715 (2011). |
| 138 | Asymmetric Mannich Reaction of Imines Derived from Aliphatic and Aromatic Aldehydes Catalyzed by Diarylprolinol Silyl Ether T. Urushima, H. Ishikawa and Y. Hayashi Chem. Eur. J. 17, 8273 (2011). |
| 137 | Organocatalyzed Michael Addition of Aldehydes to Nitro Alkenes - Generally Accepted Mechanism Revisited and Revised. Krystyna Patora-Komisarska, Meryem Benohoud, Hayato Ishikawa, Dieter Seebach and Yujiro Hayashi Helvetica Chemica Acta, 94, 719 (2011). |
| 136 | Oxidative and Enantioselective Cross-Coupling of Aldehydes and Nitromethane Catalyzed by Diphenylprolinol Silyl Ether Y. Hayashi, T. Itoh, H. Ishikawa Angew. Chem., Int. Ed., 50, 3920 (2011). Hot Paper |
| 135 | Asymmetric One-Pot Four-Component Coupling Reaction: Synthesis of Substituted Tetrahydropyrans Catalyzed by Diphenylprolinol Silyl Ether H. Ishikawa, S. Sawano, Y. Yasui, Y. Shibata and Y. Hayashi Angew. Chem., Int. Ed., 50, 3774 (2011). |
| 134 | One-Pot Synthesis of Chiral α-Substituted β,γ-Epoxy Aldehyde Derivatives through an Asymmetric Aldol Reaction of Chloroacetaldehyde Y. Hayashi, Y. Yasui, T. Kawamura, M. Kojima and H. Ishikawa Angew. Chem., Int. Ed., 50, 2804 (2011). |
| 133 | Diarylprolinol in the Direct Asymmetric Aldol Reaction of Trifluoromethylacetaldehyde Ethyl Hemiacetal with Aldehyde Y. Hayashi, Y. Yasui, T. Kawamura, M. Kojima and H. Ishikawa Synlett, 485, (2011). |
| 132 | One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by a Diphenylprolinol Silyl Ether H. Ishikawa, M. Honma,and Y. Hayashi Angew. Chem.,Int. Ed., 50, 2824 (2011). Very Important Paper |
| 2010 | |
| 131 | Asymmetric Epoxidation of α-Substituted Acroleins Catalyzed by Diphenylprolinol Silyl Ether B. P. Bondzic, T. Urushima, H. Ishikawa, and Y. Hayashi Org.Lett., 12, 5434 (2010). |
| 130 | High-Yielding Synthesis of the Anti-Influenza Neuraminidase Inhibitor (−)-Oseltamivir by Two “One-Pot” Sequences H. Ishikawa, T. Suzuki, H. Orita, T. Uchimaru and Y. Hayashi Chem. Eur. J., 16, 12616 (2010). |
| 129 | Enantio- and Diastereoselective Synthesis of Piperidines by Coupling of Four Components in a “One-Pot” Sequence Involving Diphenylprolinol Silyl Ether Mediated Michael Reaction T. Urushima, D. Sakamoto, H. Ishikawa, and Y. Hayashi Org.Lett., 12, 4588 (2010). Abstracted in SYNFACTS, 12, 1420, (2010). |
| 128 | Formal Total Synthesis of Fostriecin by 1,4-Asymmetric Induction with an Alkyne-Cobalt Complex Y. Hayashi, H. Yamaguchi, M. Toyoshima, K. Okado, T. Toyo, M. Shoji Chem. Eur. J., 16, 10150 (2010). |
| 127 | Polymeric Ethyl Glyoxylate in an Asymmetric Aldol Reaction Catalyzed by Diarylprolinol T. Urushima, Y. Yasui, H. Ishikawa, and Y. Hayashi Org.Lett., 12, 2966 (2010). |
| 126 | One-pot synthesis of chiral bicyclo[3.3.0]octatrienes using diphenylprolinol silyl ether-mediated ene-type reaction H. Gotoh, H. Ogino, H. Ishikawa, and Y. Hayashi Tetrahedron, 66, 4894 (2010). |
| 125 | Syntheses of Fumagillin and Ovalicin J. Yamaguchi, and Y. Hayashi Chem. Eur. J., 16, 3884 (2010). |
| 2009 | |
| 124 | Diphenylprolinol Silyl Ether as a Catalyst in an Asymmetric, Catalytic, and Direct Michael Reaction of Nitroethanol with α,β - Unsaturated Aldehydes H. Gotoh, D. Okamura, H. Ishikawa, and Y. Hayashi Org.Lett., 11, 4056 (2009). |
| 123 | Structures of the Reactive Intermediates in Organocatalysis with Diarylprolinol Ethers Uros Groselj, Dieter Seebach, D. Michael Badine, W. Bernd Schweizer, Albert K. Beck, Ingo Krossing, Petra Klose, Yujiro Hayashi, Tadafumi Uchimaru Helvetica Chimica Acta., 92, 1225 (2009). |
| 122 | Asymmetric Aldol Reaction of Acetaldehyde and Isatin Derivatives for the Total Syntheses of ent-Convolutamydine E and CPC-1 and a Half Fragment of Madindoline A and B T. Itoh, H. Ishikawa, and Y. Hayashi Org.Lett., 11, 3854 (2009). |
| 121 | Total synthesis and determination of the absolute configuration of FD-838, a naturally occurring azaspirobicyclic product Y. Hayashi, K. Sankar, H. Ishikawa, Y. Nozawa, K. Mizoue, H. Kakeya Bioorganic & Medicinal Chemistry Letters, 19, 3863 (2009). |
| 120 | Diphenylprolinol silyl ether as a catalyst in an asymmetric, catalytic and direct alpha - benzoyloxylation of aldehydes H. Gotoh, Y. Hayashi Chem. Commun, 3083 (2009). |
| 119 | Conversion of Alcohols to Alkyl Aryl Sulfides by a New Type of Oxidation-Reduction Condensation Using Phenyl Diphenylphosphinite K. Kuroda, Y. Maruyama, Y. Hayashi, T. Mukaiyama Bull. Chem. Soc. Jpn., 82, 381 (2009). |
| 118 | High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (－)-Oseltamivir by Three "One-Pot" Operations H. Ishikawa, T. Suzuki, Y. Hayashi Angew. Chem. Int. Ed., 48, 1304 (2009). Hot Paper! Most accessed articles in 01/2009 : Ranked as 1st! |
| 117 | Diphenylprolinol Silyl Ether as a Catalyst in an Enantioselective, Catalytic Michael Reaction for the Formation of alpha,alpha- Disubstituted alpha - Amino Acid Derivatives Y. Hayashi, K. Obi, Y. Ohta, D. Okamura, H. Ishikawa Chem. Asian. J., 4, 246 (2009). |
| 116 | Diphenylprolinol Silyl Ether Catalysis in an Asymmetric Formal Carbo [3 + 3] Cycloaddition Reaction via a Domino Michael/Knoevenagel Condensation Y. Hayashi, M. Toyoshima, H. Gotoh, H. Ishikawa Org. Lett., 11, 45 (2009) Abstracted in SYNFACTS 2009, 327 |
| 2008 | |
| 115 | Asymmetric, Catalytic, and Direct Self-Aldol Reaction of Acetaldehyde Catalyzed by Diarylprolinol Y. Hayashi, S. Samanta, T. Itoh , H. Ishikawa Org. Lett.,10, 5581, (2008) |
| 114 | Direct Organocatalytic Mannich Reaction of Acetaldehyde: An Improved Catalyst and Mechanistic Insight from a Computational Study Y. Hayashi, T. Okano, T. Itoh, T. Urushima, H. Ishikawa, T. Uchimaru Angew. Chem. Int. Ed., 47, 9053 (2008). |
| 113 | Stereospecific Synthesis of sec- and tert-Alkyl Azides from Alcohols and Trimethylsilyl Azide by a New Type of Oxidation–Reduction Condensation Using Phenyl Diphenylphosphinite and Trimethylsilylmethyl Azide T. Mukaiyama, K. Kuroda, Y. Maruyama Y. Hayashi Chem. Lett., 37, 1072 (2008). |
| 112 | Stereospecific synthesis of alkyl aryl sulfides from alcohols and 2-sulfanylbenzothiazole using aryl diphenylphoshinite and azide compounds by a new type of oxidation-reduction condensation K. Kuroda, Y. Maruyama, Y. Hayashi, T. Mukaiyama Chem. Lett., 37, 836 (2008). |
| 111 | Epoxyquinol B, a Naturally Occurring Pentaketide Dimer, Inhibits NF-kB Signaling by Crosslinking TAK1 H. Kamiyama, T. Usui, H. Sakurai, M. Shoji, Y. Hayashi, H. Kakeya, H. Osada Biosci. Biotechnol. Biochem., 72, 1894 (2008). |
| 110 | Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR H. Kamiyama, H. Kakeya, T. Usui, K. Nishikawa, M. Shoji, Y. Hayashi, H. Osada Oncology Research, 17, 11 (2008). |
| 109 | Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation H. Kamiyama, T. Usui, M. Uramoto, H. Takagi, M. Shoji, Y. Hayashi, H. Kakeya, H. Osada J. Antibiotics, 61, 94 (2008). |
| 108 | The Asymmetric Total Synthesis of (+)-Cytotrienin A, an Ansamycin-Type Anticancer Drug Yujiro Hayashi, Mitsuru Shoji, Hayato Ishikawa, Junichiro Yamaguchi, Tomohiro Tamura, Hiroki Imai, Yosuke Nishigaya, Kenichi Takabe, Hideaki Kakeya, Hiroyuki Osada Angew. Chem. Int. Ed., 47, 6657 (2008). Abstracted in SYNFACTS 2009, 247 |
| 107 | Asymmetric Diels-Alder Reactions of alpha,beta-Unsaturated Aldehydes Catalyzed by a Diarylprolinol Silyl Ether Salt in the Presence of Water Yujiro Hayashi, Sampak Samanta, Hiroaki Gotoh, Hayato Ishikawa Angew. Chem. Int. Ed., 47, 6634 (2008). |
| 106 | Preparation of Alkyl Aryl Sulfides from Alcohols and 2-Sulfanylbenzothiazole by a New Type of Oxidation–Reduction Condensation Using Aryl Diphenylphosphinite and Benzoquinone Derivatives Kiichi Kuroda, Yujiro Hayashi, Teruaki Mukaiyama Chem. Lett., 37, 592 (2008). |
| 105 | The Effectiveness of Proteinogenic Amino Acids in the Asymmetric Aldol Reaction in DMSO and Aqueous DMSO Yujiro Hayashi, Takahiko Itoh, Norio Nagae, Masahiro Ohkubo, Hayato Ishikawa Synlett, 2008, 1565. |
| 104 | Asymmetric Michael Reaction of Acetaldehyde Catalyzed by Diphenylprolinol Silyl Ether Yujiro Hayashi, Takahiko Itoh, Masahiro Ohkubo, Hayato Ishikawa Angew. Chem. Int. Ed., 47, 4722 (2008). |
| 103 | Diphenylprolinol Silyl Ether as a Catalyst in an Enantioselective, Catalytic, Formal Aza [3+3] Cycloaddition Reaction for the Formation of Enantioenriched Piperidines Yujiro Hayashi, Hiroaki Gotoh, Ryouhei Masui, Hayato Ishikawa Angew. Chem. Int. Ed., 47, 4012 (2008). Hot Paper! Abstracted in SYNFACTS 2008, 764 |
| 102 | Formal Total Synthesis of Fostriecin via 1,4-Asymmetric Induction Using Cobalt-Alkyne Complex Yujiro Hayashi, Hirofumi Yamaguchi, Maya Toyoshima, Kotaro Okado, Takumi Toyo, and Mitsuru Shoji Org. Lett. 10, 1405 (2008). Abstracted in SYNFACTS 2008, 899 |
| 101 | Proline-Mediated Enantioselective Construction of Tetrahydropyrans via a Domino Aldol/Acetalization Reaction Damien Hazelard, Hayato Ishikawa, Daisuke Hashizume, Hiroyuki Koshino, and Yujiro Hayashi Org. Lett. 10, 1445 (2008). Abstracted in SYNFACTS 2008, 762 |
| 100 | A Diarylprolinol in an Asymmetric, Catalytic, and Direct Crossed-Aldol Reaction of Acetaldehyde Yujiro Hayashi, Takahiko Itoh, Seiji Aratake, Hayato Ishikawa, Angew. Chem. Int. Ed., 47, 2082 (2008). This paper is dedicated to Prof. E. J. Corey on the occasion of his 80th birthday. Hot Paper! Abstracted in SYNFACTS 2008, 533 |
| 99 | 1,4-Asymmetric Induction using a Cobalt Alkyne Complex, Yujiro Hayashi, Hirofumi Yamaguchi, Maya Toyoshima, Satoshi Nasu, Koji Ochiai, and Mitsuru Shoji Organometallics, 27, 163 (2008). |
| 98 | Direct Asymmetric alpha-Amination of Cyclic Ketones Catalyzed by Siloxyproline, Yujiro Hayashi, Seiji Aratake, Yoshinaga Imai, Kazuhiro Hibino, Qi-Yin Chen, Junichiro Yamaguchi, Tadafumi Uchimaru Chem. Asian J. 3, 225 (2008). This paper is dedicated to Prof. Teruaki Mukaiyama on the occasion of his 80th birthday. |
| 97 | Organic Solvent-Free, Enantio- and Diastereoselective, Direct Mannich Reaction in the Presence of Water, Yujiro Hayashi, Tatsuya Urushima, Seiji Aratake, Tsubasa Okano, and Kazuki Obi, Org. Lett. 10, 21 (2008). |
| 2007 | |
| 96 | Chemistry of Epoxyquinols A, B, and C and Epoxytwinol A Mitsuru Shoji, Yujiro Hayashi European Journal of Organic Chemistry, 23, 3783 (2007) |
| 95 | Diphenylprolinol Silyl Ether as Catalyst of an Asymmetric, Catalytic, and Direct Michael Reaction of Nitroalkanes with α,β -Unsaturated Aldehydes, Hiroaki Gotoh, Hayato Ishikawa, Yujiro Hayashi, Org. Lett., 9, 5307 (2007). Most-Accessed Articles: October-December, 2007 : Ranked as 15th! |
| 94 | Highly Diastereo- and Enantioselective Direct Aldol Reactions of Aldehydes and Ketones Catalyzed by Siloxyproline in the Presence of Water, Seiji Aratake, Takahiko Itoh, Tsubasa Okano, Norio Nagae, Tatsunobu Sumiya, Mitsuru Shoji, Yujiro Hayashi, Chem. Eur. J., 13, 10246 (2007). |
| 93 | Conversion of tertiary alcohols to tert-alkyl azides by way of quinone-mediated oxidation-reduction condensation using alkyl diphenylphosphinites, Kiichi Kuroda, Yujiro Hayashi and Teruaki Mukaiyama, Tetrahedron, 63, 6358 (2007). |
| 92 | Organocatalyst-Mediated Enantioselective Intramolecular Aldol Reaction Featuring the Rare Combination of Aldehyde as Nucleophile and Ketone as Electrophile Y. Hayashi, H. Sekizawa, J. Yamaguchi, H. Gotoh, J. Org. Chem., 72, 6493 (2007). Most-Accessed Articles: July-September, 2007 : Ranked as 8th! |
| 91 | Diarylprolinol Silyl Ether as Catalyst of an exo-Selective, Enantioselective Diels-Alder Reaction H. Gotoh, Y. Hayashi, Org. Lett., 9, 2859 (2007). |
| 90 | Diphenylprolinol Silyl Ether as a Catalyst in an Enantioselective, Catalytic, Tandem Michael/Henry Reaction for the Control of Four Stereocenters Y. Hayashi, T. Okano, S. Aratake, D. Hazelard, Angew. Chem. Int. Ed., 46, 4922 (2007). |
| 89 | Small organic molecule in enantioselective, direct aldol reaction in water, S. Aratake, T. Itoh, T. Okano, T. Usui, M. Shoji and Y. Hayashi, Chem. Commun., 2007, 2524. |
| 88 | L-Proline-catalyzed enantioselective one-pot cross-Mannich reaction of aldehydes, Y Hayashi, T. Urushima, W. Tsuboi, M. Shoji, Nature Protocols 2, 113-118 (01 Feb 2007) . |
| 87 | Ultracentrifuge-mediated Diels-Alder Reaction in a Two-phase System of Water and Chloroform, Y. Hayashi, M. Takeda, M. Shoji, M. Morita, Chem. Lett., 36, 68-69 (2007). This paper is dedicated to Prof. Teruaki Mukaiyama on the occasion of his 80th birthday. |
| 86 | Dry and Wet Prolines for Asymmetric Organic-Solvent-Free Aldehyde-Aldehyde and Aldehyde-Ketone Aldol Reactions, Y. Hayashi, S. Aratake, T. Itoh, T. Okano, T. Sumiya, M. Shoji, Chem. Commun. 2007, 957. |
| 2006 | |
| 85 | Preparation of tert-Alkyl Azides from Tertiary Alcohols by Way of Benzoquinone-mediated Oxidation-Reduction Condensation, K. Kuroda, N. Kaneko, Y. Hayashi, T. Mukaiyama, Chem. Lett., 35, 1432-1433 (2006). |
| 84 | In Water or in the Presence of Water? , Y. Hayashi, Angew. Chem. Int. Ed.,
45, 8103 (2006) |
| 83 | Enantio- and Diastereoselective Total Synthesis of (+)-Panepophenanthrin, a Ubiquitin-Activating Enzyme Inhibitor, and Biological Properties of Its New Derivatives, M. Matsuzawa, H. Kakeya, J. Yamaguchi, M. Shoji, R, Onose, H. Osada, Y. Hayashi, Chem. Asian. J., 1, 845(2006).  |
| 82 | Enantioselective Ene Reaction of Cyclopentadiene and ,-Enals Catalyzed by a Diphenylprolinol Silyl Ether H. Gotoh, R. Masui, H. Ogino, M. Shoji, Y. Hayashi, Angew. Chem. Int. Ed. 45 6853 (2006). |
| 81 | Combined Proline–Surfactant Organocatalyst for the Highly Diastereo- and
Enantioselective Aqueous Direct Cross-Aldol Reaction of Aldehydes, Y. Hayashi*,
S. Aratake, T. Okano, J. Takahashi, T. Sumiya, M. Shoji, Angew. Chem. Int.
Ed. 45, 5527(2006). |
| 80 | Large Nonlinear Effect Observed in the Enantiomeric Excess of Proline in Solution and That in the Solid State, Y. Hayashi*, M. Matsuzawa, J. Yamaguchi, S. Yonehara, Y. Matsumoto, M. Shoji, D. Hashizume, H. Koshino, Angew. Chem. Int. Ed. 45, 4593 (2006). |
| 79 | Computational Study on the Reaction Mechanism of the Key Thermal [4 + 4]
Cycloaddition Reaction in the Biosynthesis of Epoxytwinol A, I. Shiina,
T. Uchimaru, M. Shoji, H. Kakeya, H. Osada, and Y. Hayashi, Org. Lett.,
8, 1041 (2006). |
| 78 | Highly Diastereo- and Enantioselective Direct Aldol Reactions in Water, Y. Hayashi, T. Sumiya, J. Takahashi, H. Gotoh, T. Urushima, M. Shoji, Angew. Chem. Int. Ed. 45, 958 (2006). |
| 77 | Concise Enantio- and Diastereoselective Total Syntheses of Fumagillol,
RK-805, FR65814, Ovalicin, and 5-Demethylovalicin J. Yamaguchi, M. Toyoshima,
M. Shoji, H. Kakeya, H. Osada, Y. Hayashi, Angew. Chem. Int. Ed., 45, 789
(2006). |
| 2005 | |
| 76 | Enantio- and Diastereoselective Total Synthesis of EI-1941-1, -2, and -3,
Inhibitors of Interleukin-1 Converting Enzyme, and Biological Properties
of Their Derivatives, M. Shoji, T. Uno, H. Kakeya, R. Onose, I. Shiina,
H. Osada, and Y. Hayashi, J. Org. Chem., 70, 9905 (2005). |
| 75 | RKTS-33, an Epoxycyclohexenone Derivative That Specifically Inhibits Fas Ligand-Dependent Apoptosis in CTL-Mediated Cytotoxicity, T. Mitsui, Y. Miyake, H. Kakeya, Y. Hayashi, H. Osada, T. Kataoka, Biosci. Biotechnol. Biochem., 69, 1923-1928 (2005). |
| 74 | Cysteine-Derived Organocatalyst in a Highly Enantioselective Intramolecular Michael Reaction, Y. Hayashi, H. Gotoh, T. Tamura, H. Yamaguchi, R. Masui, and M. Shoj, J. Am. Chem Soc, 127, 16028 (2005). |
| 73 | The Direct, Enantioselective, One-Pot, Three-Component,Cross-Mannich Reaction
of Aldehydes: The Reason for the Higher Reactivity of Aldimine versus Aldehyde
in Proline-Mediated Mannich and Aldol Reactions, Y. Hayashi, T. Urushima,
M. Shoji, T. Uchimaru, I. Shiina, Adv. Synth. Catal., 347, 1604 (2005).invited
paper of special issue dedicated to C-C bond formation. |
| 72 | The stereoselective synthesis of α-substituted β-amino secondary alcohols based on the proline-mediated, asymmetric, three-component Mannich reaction and its application to the formal total synthesis of nikkomycins B and Bx, Y. Hayashi, T. Urushima, M. Shin and M. Shoji Tetrahedron, 48, 11393 (2005). Invited paper of the special issue dedicated to Multicomponent Reactions. |
| 71 | The First Asymmetric Total Synthesis of Synerazol, an Antifungal Antibiotic,
and Determination of its Absolute Stereochemistry, Y. Hayashi, M. Shoji,
T. Mukaiyama, H. Gotoh, S. Yamaguchi, M. Nakata, H. Kakeya, H. Osada, J.
Org. Chem.,70, 5643 (2005). |
| 70 | Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric
Michael Reaction of Aldehydes and Nitroalkenes, Y. Hayashi, H. Gotoh, T.
Hayashi, M. Shoji, Angew. Chem. Int. Ed., 44, 4212-4215 (2005). |
| 69 | Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity, Y. Nagumo, H. Kakeya, M. Shoji, Y. Hayashi, N. Dohmae, H. Osada, Biochem. J., 387, 835-840 (2005). |
| 68 | Determination by asymmetric total synthesis of the absolute configuration
of lucilactaene, a cell cycle inhibitor in p53-transfected cells, J. Yamaguchi,
H. Kakeya, T. Uno, M. Shoji, H. Osada, and Y. Hayashi, Angew. Chem. Int.
Ed., 44, 3110-3115 (2005). |
| 67 | Synthesis of a- and/or g-benzoyloxy-a,b-enones from a-halo-a,b-enones, Y. Hayashi, M. Shoji, and S. Kishida, Tetrahedron Lett. 46, 681-685 (2005). |
| 66 | The Total Synthesis of Epoxyquinols A, B, C and Epoxytwinol A and the Reactivity
of a 2H-Pyran Derivative as the Diene Component in the Diels-Alder Reaction,
M. Shoji, H. Imai, M. Mukaida, K. Sakai, H. Kakeya, H. Osada, and Y. Hayashi,
J. Org. Chem. 70, 79-91 (2005). |
| 2004 | |
| 65 | Stereoselective Total Synthesis of ent-EI-1941-2 and Epi-ent-EI-1941-2,
M. Shoji, T. Uno, and Y. Hayashi, Org. Lett., 6, 4535-4538 (2004). |
| 64 | A. Highly Active 4-Siloxyproline Catalyst for Asymmetric Synthesis. Y.
Hayashi, J. Yamaguchi, K. Hibino, T. Sumiya, T. Urushima, M. Shoji, D.
Hashizume, and H. Koshino, Adv. Synth. Catal., 346, 1435-1439 (2004). |
| 63 | Structure-activity relationships of epolactaene derivatives: structural
requirements for inhibition of Hsp60 chaperone activity, Y. Nagumo, H.
Kakeya, J. Yamaguchi, T. Uno, M. Shoji, Y. Hayashi, H. Osada, Bioorg. Med.
Chem. Lett., 14, 4425-4429 (2004). |
| 62 | Direct Proline-Catalyzed Asymmetric a-Aminoxylation of Aldehydes and Ketones, Y. Hayashi, J. Yamaguchi, T. Sumiya, K. Hibino, M. Shoji, J. Org. Chem. 69, 5966-5973 (2004). |
| 61 | The Chiral Diamine Mediated Asymmetric Baylis-Hillman Reaction, Y. Hayashi,
T. Tamura, M. Shoji, Adv. Synth. Catal., 346, 1106-1110 (2004). |
| 60 | Application of high pressure, induced by water freezing, to the direct
asymmetric aldol reaction, Y. Hayashi, W. Tsuboi, M. Shoji, N. Suzuki,
Tetrhedron Lett., 45, 4353-4356 (2004). |
| 59 | Different Reaction Modes for the Oxidative Dimerization of Epoxyquinols and Epoxyquinones. Importance of Intermolecular Hydrogen-Bonding, M. Shoji, H. Imai, I. Shiina, H. Kakeya, H. Osada, Y. Hayashi, J. Org. Chem., 69, 1548-1556 (2004). |
| 58 | Direct Proline-Catalyzed Asymmetric a-Aminoxylation of Ketones, Y. Hayashi,
J. Yamaguchi, T. Sumiya, M. Shoji, Angew. Chem. Int Ed., 43, 1112-1115
(2004). |
| 2003 | |
| 57 | Direct proline catalyzed asymmetric a-aminooxylation of aldehydes, Y. Hayashi,
J. Yamaguchi, K. Hibino, M. Shoji, Tetrahedron Lett., 44, 8293-8296 (2003).
|
| 56 | Novel Non-peptide Inhibitors Targeting Death Receptor-Mediated Apoptosis,
H. Kakeya, Y. Miyake, M. Shoji, S. Kishida, Y. Hayashi, T. Kataoka, H.
Osada, Bioorganic & Medical Chem. Lett., 13, 3743-3746 (2003). |
| 55 | Application of High Pressure Induced by Water-Freezing to the Direct Catalytic
Asymmetric Three-Component List-Barbas-Mannich Reaction, Y. Hayashi, W.
Tsuboi, M. Shoji, N. Suzuki, J. Am. Chem. Soc., 125, 11208-11209 (2003).
|
| 54 | Reaction Modes of Oxidative Dimerization of Epoxycyclohexenols, M. Shoji, S. Kishida, Y. Kodera, I. Shiina, H. Kakeya, H. Osada, Y. Hayashi, Tetrahedron Lett., 44, 7205-7207 (2003). |
| 53 | The Diect and Enantioselective, One-pot, Three-Component, Cross-Mannich
Reaction of Aldehydes, Y. Hayashi, W. Tsuboi, I. Ashimine, T. Urushima,
M. Shoji, K. Sakai, Angew. Chem. Int. Ed., 42, 3677-3680 (2003). |
| 52 | Asymmetric Total Synthesis of Pseurotin A, Y. Hayashi, M. Shoji, S. Yamaguchi,
T. Mukaiyama, J. Yamaguchi, H. Kakeya, H. Osada, Org. Lett., 5, 2287-2290
(2003). |
| 2002 | |
| 51 | A Practical Total Synthesis of Both Enantiomers of Epoxyquinols A and B,
M. Shoji, S. Kishida, M. Takeda, H. Kakeya, H. Osada, and Y. Hayashi, Tetrahedron
Lett., 43, 9155-9158 (2002). |
| 50 | The Baylis-Hillman Reaction under High Pressure Induced by Water-Freezing,
Y. Hayashi, K. Okado, I. Ashimine, and M. Shoji, Tetrahedron Lett., 43,
8683-8686 (2002). |
| 49 | Asymmetric Total Synthesis of (-)-Azaspirene, a Novel Angiogenesis Inhibitor,
Y. Hayashi, M. Shoji, J. Yamaguchi, K. Sato, S. Yamaguchi, T. Mukaiyama,
K. Sakai, Y. Asami, H. Kakeya, and H. Osada, J. Am. Chem. Soc., 124, 12078-12079
(2002). |
| 48 | The Diastereoelective Asymmetric Total Synthesis of NG-391, a Neuronal Cell-Protecting Molecule, Y. Hayashi, J. Yamaguchi, and M. Shoji, Tetrahedron, 58, 9839-9846 (2002). |
| 47 | Diastereoselective Total Synthesis of Both Enantiomers of Epolactaene,
Y. Hayashi, J. Kanayama, J. Yamaguchi, and M. Shoji, J. Org. Chem. 67,
9443-9448 (2002). |
| 46 | The HfCl4-Mediated Diels-Alder Reaction of Furan, Y. Hayashi, M. Nakamura,
S. Nakao, T. Inoue, and M. Shoji, Angew. Chem. Int. Ed., 41, 4079-4082
(2002). |
| 45 | A Novel Adenine Nucleotide Translocase Inhibitor, MT-21, Induces Cytochrome c Release by a Mitochondrial Permeability Transition-independent Mechanism, K. Machida, Y. Hayashi, and H. Osada, J. Bio. Chem., 277, 31243-31248 (2002). |
| 44 | Total Synthesis of (+)-Epoxyquinols A and B, M. Shoji, J. Yamaguchi, H.
Kakeya, H. Osada, and Y. Hayashi, Angew. Chem. Int. Ed., 41, 3192-3194
(2002). |
| 43 | b-Ketothioester as a reactive Knoevenagel donor, Y. Hayashi, Y. Miyamoto, and M. Shoji, Tetrahedron Lett., 43, 4079-4082 (2002). |
| 42 | Oxidative Double Bond Cleavage of a-Substituted Styrenes with Molecular Oxygen, Y. Hayashi, M. Takeda, Y. Miyamoto, and M. Shoji, Chem. Lett., 2002, 414-415. |
| 41 | Application of High Pressure Induced by Water-freezing to the Michael Reaction of Alcohols with a,b-Enones, Y. Hayashi, and K. Nishimura, Chem. Lett., 2002, 296-297. |