• Mr. Hatano was hired as JSPS Research Fellowship for Young Scientists (DC1) !!

  • Publication list was updated.

    Secondary Amine-Mediated Domino Reaction for the Synthesis of
    Substituted Quinolines from Dicyanoalkenes and Eneynals
    Y. Hayashi*, X.-L. Han, N. Mori
    Chem. Eur. J., ASAP.
    https://doi.org/10.1002/chem.202301093

  • Prof. Hayashi's article was introduced in Chematels.

    https://chematels.com/article/clfm2318n20pv0bzv1xy1elzv

  • Our paper is one of the most read Nature Communications articles in chemistry and materials sciences in 2022.

    DOI:https://doi.org/10.1038/s41467-022-34916-z

  • Mr. Odaira won ''President's Award''.

  • Mr. Terunuma won ''令和4年度 化学専攻賞''.

    https://www.sci.tohoku.ac.jp/news/20230310-12534.html

  • Our paper was introduced in Chemistry World

    https://www.chemistryworld.com/news/streamlined-synthesis-of-quinine-showcases-sustainable-organic-strategy/4016776.article



  • Our paper has been selected as an Eiditor's highlight in Nature Communication

    DOI:https://doi.org/10.1038/s41467-022-34916-z

  • Publication list was updated.

    Organocatalyst-mediated five-pot synthesis of (-)-quinine
    T. Terunuma, Y. Hayashi*
    Nat. Commun. 2022, 13, 7503.
    DOI:https://doi.org/10.1038/s41467-022-34916-z



    The press release
    Tohoku Univ. HP
    https://www.tohoku.ac.jp/japanese/2022/12/press20221208-02-quinine.html
    Graduate School of Science and Fuculty of Science, Tohoku University HP
    https://www.sci.tohoku.ac.jp/news/20221208-12401.html
    Twitter
    https://twitter.com/sci_koho/status/1600673681008885760

  • Publication list was updated.

    Cover Picture
    DOI: 10.1055/a-1846-5007

  • Publication list was updated.

    Stereoselective Construction of Fluorinated Quaternary Stereogenic Centers
    via an Organocatalytic Asymmetric exo-Selective Diels-Alder Reaction in the Presence of Water
    B. P. Bondzic, K. Daskalakis, T. Taniguchi, K. Monde, Y. Hayashi*
    Org. Lett. 2022, 24, 7455.
    doi.org/10.1021/acs.orglett.2c03043

  • Our paper was highlighted in Synform.

    DOI: 10.1055/s-0040-1720573

  • Prof. Hayashi is invited to IASOC 2022 (Ischia Advanced School of Organic Chemistry) in Italy, September 23-26.

    http://www.iasoc.it/home/iasoc-2022/

  • Publication list was updated.

     Diarylprolinol as an Effective Organocatalyst in Asymmetric Cross-aldol Reactions
    of Two Different Aldehydes
    Y. Hayashi*
    Chem. Rec.     2022, e202200159.
    DOI:org/10.1002/tcr.202200159

  • Prof. Hayashi wrote a review about Nobel prize chemistry 2021 in Kagaku of Iwanami Shoten.
    岩波「科学」2022年3月号

  • Prof. Hayashi received "第21回GSC賞　文部科学大臣賞"

    Title:有機触媒を用いた環境調和型合成プロセスの開発

    また、本受賞が化学工業日報に掲載されました。
    全編やその他の記事の閲覧には本誌をご購読ください。

  • Publication list was updated.

     Diphenylprolinol Silyl Ether Catalyzed Asymmetric Formal Carbo [3+3] Cycloaddition Reaction
    of Isopropylidenemalononitrile and α,β-Unsaturated Aldehyde
    N. Umekubo, X. Han, N. Mori, Y Hayashi*
    Eur. J. Org. Chem. 2022, ASAP.
    DOI:org/10.1002/ejoc.202200603

  • Publication list was updated.

    Highly Sterically Hindered Peptide Bond Formation between α,α-Disubstituted α-Amino Acids
    and N-Alkyl Cysteines Using α,α-Disubstituted α-Amidonitrile
    X. Wang, J. Li, Y. Hayashi*
    J. Am. Chem. Soc. 2022, ASAP.
    DOI:org/10.1021/jacs.2c02993

     Asymmetric Michael Reaction of Aldehydes and Nitroalkenes
    Y. Hayashi*
    Org. Synth.     2022, 99, 68.
    DOI: 10.15227/orgsyn.099.0068

  • Mr. Terunuma won the Best Short Presentation Award at 33rd Banyu Sendai Symposium.

    Title:Pot-Economical Synthesis of (－)-Quinine Using Organocatalyst

  • Prof. Hayashi received "Awards for Science and Technology, The Commendation for Science
    and Technology by the Minister of Education, Culture, Sports, Science and Technology"

    林雄二郎教授が令和4年度 文部科学大臣表彰　科学技術賞を受賞されました。
    業績名：環境調和型有機触媒と超短時間高効率天然物合成の研究
    リンク：文部科学省website 令和4年度科学技術分野の文部科学大臣表彰受賞者の決定について

  • Publication list was updated.

    Asymmetric Michael reaction of malononitrile and
    α,β-unsaturated aldehydes catalyzed by diarylprolinol silyl ether
    Y. Hayashi*, Y. Hatano, N. Mori
    Synlett     2022, ASAP.
    DOI: 10.1055/a-1846-5007
    Invited cluster paper: Development and application of
    novel ligands/catalysts and mechanistic studies on catalysis

    Asymmetric flow reactions catalyzed by immobilized diphenylprolinol alkyl ether:
    Michael reaction and domino reactions
    Y. Hayashi*, S. Hattori, S. Koshino
    Chem Asian J. 2022, ASAP.
    DOI:org/10.1002/asia.202200314

    Diarylprolinol with Trifluoromethyl Substituents and Diphenylprolinol-Derived
    Perfluoroalkanesulfonamide as Organocatalysts in the Cross-Aldol Reaction of Aldehydes
    Y. Hayashi*, M. Tomikawa, N. Mori
    Adv. Synth. Catal. 2022, ASAP.
    DOI:org/10.1002/adsc.202200266
    Invited paper of the special issue dedicated to Prof. Andreas Pfaltz.

  • Mr. Odaira won the award "青葉理学振興会奨励賞".

  • Publication list was updated.

     Catalytic asymmetric Michael reaction of methyl alkynyl ketone
    catalyzed by diphenylprolinol silyl ether
    N. Umekubo, Y. Hayashi*
    ACS Org. Inorg. Au, 2022, ASAP.
    DOI: org/10.1021/acsorginorgau.1c00054

     Asymmetric Synthesis of Pentasubstituted Cyclohexanes
    through Diphenylprolinol Silyl Ether Mediated Domino Michael/Michael Reaction
    A. S. Odoh, L. Aidanpää, N. Umekubo, H. Matoba, N. Mori, Y. Hayashi*
    Eur. J. Org. Chem. 2021, 6670.
    DOI: org/10.1002/ejoc.202101106

    Synthesis of bicyclo[2.2.2]octanes with a quaternary bridgehead carbon
    by diphenylprolinol silyl ether mediated domino reaction
    N. Umekubo, T. Taniguchi, K. Monde, Y. Hayashi*
    Asian. J. Org. Chem. 2021, 10, 3261.
    DOI: org/10.1002/ajoc.202100573

     Enantiodivergent one-pot synthesis of axially chiral biaryls using organocatalyst-mediated
    enantioselective domino reaction and central-to-axial chirality conversion
    S. Koshino, T. Taniguchi, K. Monde, E. Kwon, Y. Hayashi*
    Chem. Eur. J    . 2021, 27, 15786.
    DOI: org/10.1002/chem.202102797

  • Mr. Hatano won the Best Oral Presentation Award at International Summer Seminar on Organic Chemistry.

    Title: Organocatalyst mediated asymmetric Michael reaction of malononitrile to α,β-unsaturated aldehyde

  • Prof. Hayashi is invited to World Class Professor 2021.

  • This article was selected as Vol. 94, No. 3, BCSJ Award Article.

    Amphiphilic Immobilized Diphenylprolinol Alkyl Ether Catalyst on PS-PEG Resin
    Seitaro Koshino, Shusuke Hattori, Shota Hasegawa, Naoki Haraguchi, Takeshi Yamamoto,
    Michinori Suginome, Yasuhiro Uozumi, and Yujiro Hayashi *
    Bull. Chem. Soc. Jpn. 2021, 94, 790.
    https://doi.org/10.1246/bcsj.20200355

  • Publication list was updated.

    Three-pot synthesis of chiral anti-1,3-diols through asymmetric organocatalytic aldol
    and Wittig reactions followed by epoxidation and reductive opening of the epoxide
    Y. Hayashi*, M. Tomikawa, N. Mori
    Org. Lett., 2021, 23, 5896.
    DOI: 10.1021/acs.orglett.1c01986

    Asymmetric synthesis of functionalized 9-methyldecalins
    using a diphenylprolinol silyl ether-mediated domino Michael/Aldol reaction
    Y. Hayashi*, H. A. Salazar, S. Koshino
    Org. Lett.    , 2021, 23, 6654.
    DOI: 10.1021/acs.orglett.1c02196

    Halogen Bonding of N-Halosuccinimides with Amines
    and Effects of Brønsted Acids in Quinuclidine-Catalyzed Halocyclizations
    J. Li, E. Kwon, M. J. Lear, Y. Hayashi*
    Helv. Chim. Acta., 2021, 104, ASAP.
    DOI: org/10.1002/hlca.202100080
    Invited paper of the special issue dedicated to the 75th birthday of Prof. E. P. Kundig.

  • Cover picture was updated.
    LINK

  • Dr. Umekubo (Nagoya Univ.) won the CSJ Student Presention Award 2021 at the CSJ 101st Annual Meeting.

    Title: ''Pot-Economical Synthesis of Prostaglandins''

  • Publication list was updated.

    Oxidative peptide bond formation of glycine–amino acid
    using 2-(aminomethyl)malononitrile as a glycine unit
    Xiaoling Wang, Jing Li and Yujiro Hayashi*
    Chem. Commun., 2021, 57, 4283.
    DOI: 10.1039/D1CC00130B

    Time Economy in Total Synthesis
    Yujiro Hayashi*
    J. Org. Chem. 2021, 86, 1.  
    This article was selected as cover picture.
    https://dx.doi.org/10.1021/acs.joc.0c01581

    Time and Pot Economy in Total Synthesis
    Yujiro Hayashi
    Acc. Chem. Res    . 2021, 54, 1385.
    https://doi.org/10.1021/acs.accounts.0c00803


    Amphiphilic Immobilized Diphenylprolinol Alkyl Ether Catalyst on PS-PEG Resin
    Seitaro Koshino, Shusuke Hattori, Shota Hasegawa, Naoki Haraguchi, Takeshi Yamamoto,
    Michinori Suginome, Yasuhiro Uozumi, and Yujiro Hayashi *
    Bull. Chem. Soc. Jpn. 2021, 94, 790.
    https://doi.org/10.1246/bcsj.20200355

    Direct Cyclopropanation of α‐Cyano β‐Aryl Alkanes by Light‐Mediated
    Single Electron Transfer Between Donor–Acceptor Pairs
    Jing Li, Martin J. Lear, Yujiro Hayashi*
    Chem. Eur. J    . 2021, 27, 5901.
    https://doi.org/10.1002/chem.202100341

  • 3/3 Event was uploaded. Link

  • 1/9 Two Ph.D course students and an assistant professor have arrived our lab.

  • Publication list was updated.

    Pot-Economical Total Synthesis of Clinprost
    Nariyoshi Umekubo and Yujiro Hayashi*
    Org. Lett. 2020, 22, 9365.
    https://doi.org/10.1021/acs.orglett.0c03616

  • Three 3rd grade students was assigned to our lab.

  • Publication list was uptated.

    Asymmetric Domino Reaction of α,β-Unsaturated Aldehydes and α-Acyl α,β-Unsaturated Cyclic Ketones Catalyzed by Diphenylprolinol Silyl Ether
    Yujiro Hayashi*, Yurina Suga, and Nariyoshi Umekubo
    Org. Lett. 2020, 22, 8603-8607
    https://doi.org/10.1021/acs.orglett.0c03190

  • Mr. Hattori won the poster award at Joint Meeting of the Tohoku Area Chemistry Societies "令和2年化学系学協会東北大会".

  • Publication list was uptated.

    Evidence for an enolate mechanism in the
    asymmetric Michael reaction of a,b-unsaturated
    aldehydes and ketones via a hybrid system of two
    secondary amine catalysts
    Nariyoshi Umekubo, Takahiro Terunuma, Eunsang Kwon and Yujiro Hayashi
    Chem. Sci., 2020, 11, 11293-11297
    https://doi.org/10.1039/D0SC03359F

  • Publication list was uptated.

    Asymmetric synthesis of Corey lactone and latanoprost
    Nariyoshi Umekubo and Yujiro Hayashi
    Eur. J. Org. Chem. 2020, 39, 6221.
    https://doi.org/10.1002/ejoc.202001063

  • This article was highlighted in OPR&D.

    Pot and time economies in the total synthesis of Corey lactone
    Nariyoshi Umekubo, Yurina Suga, and Yujiro Hayashi
    Chem. Sci., 2020, 11, 1205-1209.
    10.1039/C9SC05824A


    Cited on this

  • Publication list was updated.


    Asymmetric domino Mukaiyama Michael/Michael reaction catalyzed by diphenylprolinol silyl ether
    Nariyoshi Umekubo and Yujiro Hayashi
    Eur. J. Org. Chem. 2020, 34, 5596-5600
    https://doi.org/10.1002/ejoc.202000925

  • This article was selected as a "Cover Profile" in Chem. Eur. J.

    Inversion of the axial information during oxidative aromatization in the synthesis of axially chiral biaryls using organocatalyst as a key step
    Seitaro Koshino, Akira Takikawa, Keiichi Ishida, Tohru Taniguchi, Kenji Monde, Eunsang Kwon, Shigenobu Umemiya, Yujiro Hayashi
    Chem. Eur. J. 2020, 26, 4524-4530
    10.1002/chem.201905814

    Cover Profile

  • Our papers were selected as Top Downloaded Paper 2018-2019.

    Total Synthesis of Estradiol Methyl Ether and Its Five‐Pot Synthesis with an Organocatalyst
    Seitaro Koshino, Eunsang Kwon, Yujiro Hayashi
    Eur. J. Org. Chem., 2018, 41, 5629-5638
    DOI: 10.1002/ejoc.201800910


    Asymmetric synthesis of biaryl atropisomers using an organocatalyst‐mediated domino reaction as a key step
    Y. Hayashi, A. Takikawa, S. Koshino, K. Ishida, Chem. Eur. J. 2019, 25, 10319–10322.
    https://doi.org/10.1002/chem.201902767

  • Highly Enantioselective Access to syn-α,γ-Dihydroxycarbonyl Building Blocks via Organocatalyst-Mediated Aldol Reaction as a Key Step
    Xiaoling Wang, Genki Kawauchi, Yujiro Hayashi
    Chem. Lett. 2020, 49, 940-943
    https://doi.org/10.1246/cl.200304
  • One-pot synthesis of chiral cis-hydrindanes via diphenylprolinol silyl ether mediated domino reaction and aldol condensation
    Nariyoshi Umekubo, Ryohei Iwata, Yujiro Hayashi
    Chem. Lett.     2020, 49, 867-869
    https://doi.org/10.1246/cl.200297
  • Asymmetric Michael reaction of aldehydes and α‐cyano α,β‐unsaturated esters catalyzed by diphenylprolinol silyl ether; a facile asymmetric route to 3,4,5‐trisubstituted piperidines
    Yujiro Hayashi, Amaechi Shedrack Odoh, Nektarious Kranidiotis-Hisatomi
    ChemCatChem, 2020, 12, 2412-2415
    https://doi.org/10.1002/cctc.202000113

    This publication is part of a Special Collection on “The Catalysis of RingSynthesis”.
  • Inversion of the axial information during oxidative aromatization in the synthesis of axially chiral biaryls using organocatalyst as a key step
    Seitaro Koshino, Akira Takikawa, Keiichi Ishida, Tohru Taniguchi, Kenji Monde, Eunsang Kwon, Shigenobu Umemiya, Yujiro Hayashi
    Chem. Eur. J. 2020, 26, 4524-4530
    10.1002/chem.201905814


    Prof. Hayashi will give a plenary lecture at An International Symposium on CHANGING PARADIGMS IN PROCESS INNOVATION



    Prof. Hayashi is invited to International Conference on Recent Trends in Catalysis 2020



  • Our cover picture was introduced in website of faculty of science, Tohoku Univ.

    https://www.sci.tohoku.ac.jp/news/20200214-10951.html

  • Publication list was updated.


    Pot and time economies in the total synthesis of Corey lactone
    Nariyoshi Umekubo, Yurina Suga, and Yujiro Hayashi
    Chem. Sci., 2020, 11, 1205-1209.
    10.1039/C9SC05824A

  • Publication list was updated.

    Diarylprolinol‐Mediated Asymmetric Direct Cross‐Aldol Reaction of α,β‐Unsaturated Aldehyde as an Electrophilic Aldehyde
    Prof. Dr. Yujiro Hayashi (林雄二郎) Kaito Nagai (永井海人) Dr. Shigenobu Umemiya (梅宮茂伸)
    Chem. Asian. J. 2019, 14, 4146-4149.
    https://doi.org/10.1002/asia.201901236

  • Prof. Hayashi’s essay in August issue of “Chemistry & Chemical Industry” magazine of The Chemical Society of Japan

  • Prof. Hayashi's article in "Chemistry Today" was introduced in "Chem-Station"(LINK).


  • Publication list was updated.
    Asymmetric synthesis of biaryl atropisomers using an organocatalyst‐mediated domino reaction as a key step
    Y. Hayashi, A. Takikawa, S. Koshino, K. Ishida, Chem. Eur. J. 2019, 25, 10319–10322.
    https://doi.org/10.1002/chem.201902767


    Asymmetric Michael Reaction of α-CF3 Thioester and α,β-Unsaturated Aldehyde Catalyzed by Diphenylprolinol Silyl Ether
    Y. Hayashi, T. Yamada, M. Sato, S. Watanabe, E. Kwon, K. Iwasaki, S. Umemiya, Org. Lett. 2019, 21, 5183–5186.
    https://doi.org/10.1021/acs.orglett.9b01774

  • Mr. Takikawa won the best poster award at SSOCJ sympothium "第115回有機合成シンポジウム2019年【春】".

  • Prof. Hayashi's article was published in "Chemistry Today, May, 2019" No.578.


    Watch the rest on the journal.

  • Mr. Tomikawa won the award "青葉理学振興会奨励賞".

  • Published as part of the 30 Years SYNLETT – Pearl Anniversary Issue

    Asymmetric Synthesis of Chiral 1,3-Dimethyl Units Through a Double Michael Reaction of Nitromethane and Crotonaldehyde Catalyzed by Diphenylprolinol Silyl Ether
    Yujiro Hayashi, Shunsuke Toda
    Synlett, 2019, 30(04), 442-448
    DOI: 10.1055/s-0037-1611644

    Invited paper to the “30 years SYNLETT Pearl Anniversary Issue”


  • Our paper was highlighted in Synfacts.

    DOI: 10.1055/s-0037-1610555

  • Publication List was updated.

    Cover Picture
    https://doi.org/10.1002/ejoc.201801418

  • Publication list was updated

    Asymmetric Synthesis of Chiral 1,3-Dimethyl Units Through a Double Michael Reaction of Nitromethane and Crotonaldehyde Catalyzed by Diphenylprolinol Silyl Ether
    Yujiro Hayashi, Shunsuke Toda
    Synlett, 2019, 30(04), 442-448
    DOI: 10.1055/s-0037-1611644

  • Hayahsi wrote a Preface in Journal of Synthetic Organic Chemistry, Japan. (Yuki Gosei Kagaku Kyokaishi)

    https://doi.org/10.5059/yukigoseikyokaishi.76.1271

  • Publication list was updated.

    Sterically Congested Ester Formation from α‐Substituted Malononitrile and Alcohol by an Oxidative Method Using Molecular Oxygen
    Yujiro Hayashi, Jing Li, Hirotaka Asano, Daisuke Sakamoto
    Eur. J. Org. Chem., 2019, 2019(4), 675-677
    https://doi.org/10.1002/ejoc.201800984

  • Publication list was updated.

    Asymmetric Michael Reaction of Aldehydes and Dicyanoalkenes Catalyzed by Diphenylprolinol Silyl Ether
    Yujiro Hayashi, Nektarios Kranidiotis‐Hisatomi, Daisuke Sakamoto, Kyohei Oritani, Takuji Kawamoto, Akio Kamimura
    Eur. J. Org. Chem., 2018, 2018(48), 6843-6847
    https://doi.org/10.1002/ejoc.201800831

  • Author Profile of Prof. Hayashi has appeared:


    https://doi.org/10.1002/ejoc.201801452


  • Publication List was updated

    Domino Michael/Michael Reaction for the Formation of Chiral Spirocycles Using a Diphenylprolinol Silyl Ether
    Yujiro Hayashi, Kaito Nagai, Shigenobu Umemiya
    Eur. J. Org. Chem., 2019, 678-681
    https://doi.org/10.1002/ejoc.201801202

  • Publication List was updated

    Cover Picture
    https://doi.org/10.1002/ejoc.201801580

  • This paper was selected as Editor's Choice

    Asymmetric Michael Reaction of Aldehyde and β-Substituted α-Nitroacrylate Catalyzed by Diphenylprolinol Silyl Ether
    Daisuke Sakamoto and Yujiro Hayashi
    Chem. Lett., 2018, 47(7), 833-835
    DOI: 10.1246/cl.180273

  • Prof. Hayashi attended at the XXII International Conference on Organic SYnthesis (ICOS 22) at Florence, Italy

    https://twitter.com/22Icos/status/1042698776811581440
    https://twitter.com/EurJOC/status/1042698744872009728
    https://twitter.com/VarinderAggar11/status/1042712398598205441
    https://twitter.com/MaulideLab/status/1041419006274666499

  • Prof. Hayashi will give a plenary lecture at XXII International Conference on Organic Synthesis (ICOS 22) at Florence, Italy. (LINK)


  • Publication List was updated.


    Total Synthesis of Estradiol Methyl Ether and Its Five‐Pot Synthesis with an Organocatalyst
    Seitaro Koshino, Eunsang Kwon, Yujiro Hayashi
    Eur. J. Org. Chem., 2018, 41, 5629-5638
    DOI: 10.1002/ejoc.201800910


    有機触媒を用いた生物活性化合物の全合成、林 雄二郎、梅宮 茂伸、越野 晴太郎、ケミカルタイムス、2018年, No.3（通巻249号）link

  • Publication List was updated.

    Asymmetric Michael Reaction of Aldehyde and β-Substituted α-Nitroacrylate Catalyzed by Diphenylprolinol Silyl Ether
    Daisuke Sakamoto and Yujiro Hayashi
    Chem. Lett., 2018, 47(7), 833-835
    DOI: 10.1246/cl.180273

  • Publication List was updated.

    Autoinductive conversion of α,α-diiodonitroalkanes to amides and esters catalysed by iodine byproducts under O2
    Jing Li, Martin J. Lear and Yujiro Hayashi
    Chem. Commun., 2018,54, 6360-6363
    DOI: 10.1039/C8CC03191F

  • 06/09 Banyu Simpothium Sendai

    Mr. Umekubo Received Best Poster Award.

  • Publication List was updated.

    Prolinate Salt as a Catalyst in the syn-Selective, Asymmetric Mannich Reaction of Alkynyl Imine
    Yujiro Hayashi, Tatsuya Yamazaki, Genki Kawauchi, and Itaru Sato
    Org. Lett., Article ASAP
    DOI: 10.1021/acs.orglett.8b00728 

  • Publication List was updated.

    Enantio ‐ and Diastereoselective Synthesis of Latanoprost using an Organocatalyst
    Genki Kawauchi, Shigenobu Umemiya, Tohru Taniguchi, Kenji Monde, Yujiro Hayashi
    Chem. Eur. J., Accepted
    DOI: 10.1002/chem.201800829

  • University College London - Tohoku Organic Chemistry Symposium

    http://www.sci.tohoku.ac.jp/mediaoffice/20180313-9565.html

    see also invitation lectures.

  • Our publication was selected as inside back cover !

    Direct Asymmetric Michael Reaction of α,β-Unsaturated Aldehydes and Ketones Catalyzed by Two Secondary Amine Catalysts
    Yujiro Hayashi and Nariyoshi Umekubo
    Angew. Chem. Int. Ed. 2018, 57, 1958-1962
    DOI: 10.1002/anie.201710085

  • Publication List was updated.

    Two-pot synthesis of chiral 1,3-syn-diols through asymmetric organocatalytic aldol and Wittig reactions, followed by domino hemiacetal/oxy-Michael reactions
    Yujiro Hayashi, Takanobu Saitoh, Hiromu Arase, Genki Kawauchi, Naohiro Takeda, Yasuharu Shimasaki, and Itaru Sato
    Chem. Eur. J., ASAP
    DOI: 10.1002/chem.201705930

  • Publication List was updated.

    Direct Asymmetric Michael Reaction of α,β-Unsaturated Aldehydes and Ketones Catalyzed by Two Secondary Amine Catalysts
    Yujiro Hayashi and Nariyoshi Umekubo
    Angew. Chem. Int. Ed. 2018, 57, 1958-1962
    DOI: 10.1002/anie.201710085

  • Publication List was updated.

    Asymmetric Michael Reaction of Aldehydes and Nitroalkenes
    Yujiro Hayashi and Shin Ogasawara
    Org. Synth. 2017, 94, 252-258
    DOI: 10.15227/orgsyn.094.0252

  • Publication List was updated.

    Prolinate Salts as Catalysts for α-Aminoxylation of Aldehyde and Associated Mechanistic Insights
    Yujiro Hayashi* , Nariyoshi Umekubo, and Taku Hirama
    Org. Lett., 2017, 19, 4155–4158
    DOI: 10.1021/acs.orglett.7b01433 

  • Publication List was updated.

    Pot-economical total synthesis of estradiol methyl ether through the use of an organocatalyst
    Yujiro Hayashi, Seitaro Koshino, Kanna Ojima and Eunsang Kwon
    Angew. Chem. Int. Ed. 2017, 56, 11812-11815
    DOI: 10.1002/anie.201706046

  • Hayashi is a invited speaker at the 46th IUPAC World Chemistry Congress at Sao Paulo, Brazil on July 13, 2017.

    http://www.iupac2017.org/symposia.php#cs

  • Dr. Jing Li has been granted "the 2016 Chinese Government Award for Outstanding Self-financed Students Abroad" by China Scholarship Council.

  • Our following paper was selected as one of the Organic Letters' Top 20 most downloaded articles for the previous 12 months.

    Time Economical Total Synthesis of (−)-Oseltamivir
    Yujiro Hayashi, Shin Ogasawara
    Org. Lett., 2016, 18(14), pp 3426-3429

  • Our following paper was selected as one of the Angewandte Chemie International Edition’s most cited articles ever.

    Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric Michael Reaction of Aldehydes and Nitroalkenes
    Yujiro Hayashi, Hiroaki Gotoh, Takaaki Hayashi, Misturu Shoji
    Angew. Chem. Int. Ed. 2005, vol. 44, pp. 4212-4215
    LINK

  • Our following paper was selected as one of the Chemical Science’s most accessed articles in 2016.

    “Pot economy and one-pot synthesis”, Y. Hayashi, Chem. Sci., 2016, 7, 866-880.
    LINK

  • Enantioselective Total Synthesis of Beraprost Using Organocatalyst

    Shigenobu Umemiya, Daisuke Sakamoto, Genki Kawauchi, and Yujiro Hayashi
    Org. Lett., Article ASAP
    DOI: 10.1021/acs.orglett.7b00134

  • Hayashi is a plenary lecturer at the symposium at IIT Kharagpur, "Organic Molecules: Synthesis and Applications" (LINK).

  • Multistep Continuous-Flow Synthesis of (–)-Oseltamivir

    Synthesis, 2017, 49, 424-428.
    Ogasawara, Shin; Hayashi, Yujiro
    introduced in Thieme Chemistry

  • Invitation Lecture was uploaded

    12/26
    Dr. Takasuke Mukaiyama (eFFECTOR Therapeutics)
    Title: 英語ができないで海外に渡った学生のひとりごと

  • Mr. Arase got best postar award at 15th Symposium on Chemical Approaches to Chirality.

  • Prof. Hayashi was invited as a plenary speaker at 10th International Symposium on Integrated Synthesis (ISONIS-10) at Awaji Island, Japan from November 18-19.

  • Third year students and a master course student joined our lab.

  • Dr. Li Jing won Tohoku University Professor Fujino incentive Award for 2016

  • Prof. Hayashi was introduced in Chem-Station.

  • Asymmetric Diels–Alder Reaction of α-Substituted and β,β-Disubstituted α,β-Enals via Diarylprolinol Silyl Ether for the Construction of All-Carbon Quaternary Stereocenters

    Chem. Eur. J., 22, 1–8(DOI : 10.1002/chem.201602345)
    Yujiro Hayashi, Bojan P. Bondzic, Tatsuya Yamazaki, Yogesh Gupta, Shin Ogasawara, Tohru Taniguchi, and Kenji Monde

  • Prof. Hayashi is invited to a conference Advances in Organic Chemistry – Smolenice 2016 in Slovakia from September 4-7.


  • Our chemistry was cited at OCP

    Organocatalyzed C-C Ring Construction: The Kotsuki Synthesis of (+)-Aspidospermidine

  • Time Economical Total Synthesis of (−)-Oseltamivir

    Org. Lett.,18, 3426-3429(DOI : 10.1021/acs.orglett.6b01595)
    Yujiro Hayashi and Shin Ogasawara
    Reviewed in chemistry world
    introduced in Chemical Engineering News

  • M. course member, Etienne Gauthier, went back to France.

  • Dr. course member, Shinya Shiomi, went back to Kumamoto Univ.

  • Enantioselective Total Synthesis of RQN-18690A (18-Deoxyherboxidiene)

    Org. Lett., 18, 3382-3385(DOI : 10.1021/acs.orglett.6b01524)
    Yasunobu Matsumoto, Kazuhiro Hibino, Masahiro Yonaga, Hideaki Kakeya, and Yujiro Hayashi

  • Asymmetric Aldol Reaction of Dichloroacetaldehyde Catalyzed by Diarylprolinol

    Adv. Synth. Catal. 358, 2345-2351(DOI : 10.1002/adsc.201501111)
    Yujiro Hayashi, Daichi Nakamura, Yusuke Yasui, Kotaro Iwasaki and Hiroaki Chiba

  • Sterically Demanding Oxidative Amidation of a-Substituted Malononitriles with Amines Using O

    Angew. Chem. Int. Ed., 55,, 9060-9064(DOI : 10.1002/anie.201603399)
    Jing Li, Dr. Martin J. Lear, Prof. Dr. Yujiro Hayashi

  • Dr. course member, Shinya Shiomi, joined us from Kumamoto Univ.(for 2 month)

  • New Mr. course member, Etiene Gauthier, Hirotaka Asano, joined us.(for 4 month)

  • The DFT Calculation with NBO Analysis of E/Z Enamines Derived from a-Alkoxyaldehyde with Pyrrolidine

    Bull. Chem. Soc. Jpn., 89, 455-459 (2016)
    T. Mukaiyama, T. Uchimaru, Y. Hayashi,

  • Mechanism of Oxidative Amidation of Nitroalkanes with Oxygen and Amine Nucleophiles by Using Electrophilic Iodine

    Chem. Eur. J., 22, 5538-5542 (2016)
    Jing Li, Dr. Martin J. Lear, Prof. Dr. Eunsang Kwon, Prof. Dr. Yujiro Hayashi

  • 16O/18O Exchange of Aldehydes and Ketones caused by H218O in the Mechanistic Investigation of Organocatalyzed Michael, Mannich, and Aldol Reactions

    Chem. Eur. J., 22, 5868-5872 (2016)
    Prof. Dr. Yujiro Hayashi, Dr. Takasuke Mukaiyama, Dr. Meryem Benohoud, Dr. Nishant R. Gupta, Tsuyoshi Ono, Shunsuke Toda

  • Total Synthesis of 7,10-Epimer of the Proposed Structure of Amphidinolide N, Part II: Synthesis of C17–C29 Subunit and Completion of the Synthesis

    Chem. Eur. J., 22, 3287-3291 (2016)
    Dr. Koji Ochiai, Dr. Sankar Kuppusamy, Yusuke Yasui, Tsubasa Okano, Yasunobu Matsumoto, Dr. Nishant R. Gupta, Dr. Yohei Takahashi, Prof. Dr. Takaaki Kubota, Prof. Dr. Jun'ichi Kobayashi, Prof. Dr. Yujiro Hayashi

  • Total Synthesis of 7,10-Epimer of the Proposed Structure of Amphidinolide N, Part I: Synthesis of the C1–C13 Subunit

    Chem. Eur. J., 22, 3282-3286 (2016)
    Dr. Koji Ochiai, Dr. Sankar Kuppusamy, Yusuke Yasui, Tsubasa Okano, Yasunobu Matsumoto, Dr. Nishant R. Gupta, Dr. Yohei Takahashi, Prof. Dr. Takaaki Kubota, Prof. Dr. Jun'ichi Kobayashi, Prof. Dr. Yujiro Hayashi

  • Total synthesis of avermectin B1a revisited

    J. Antibio., 69, 31-50 (2016)
    S. Yamashita, D. Hayashi, A. Nakao, Y. Hayashi, M. Hirama,

  • Pot economy and one-pot synthesis

    Chem. Sci. , 7, 866-880 (2016) (DOI: 10.1039/C5SC02913A )
    Yujiro Hayashi

  • One-Pot Synthesis of (S)-Baclofen via Aldol Condensation of Acetaldehyde with Diphenylprolinol Silyl Ether Mediated Asymmetric Michael Reaction as a Key Step

    Org.Lett., 18, 4-7 (2016)
    Abstracted SYNFACTS 2016, 12(3), 0220
    Yujiro Hayashi, Daisuke Sakamoto, and Daichi Okamura

  • Formal Synthesis of Ezetimibe Using a Proline-mediated, Asymmetric, Three-component Mannich Reaction

    Chem.Lett., 45, 30-32 (2016)
    Yasuharu Shimasaki, Seitaro Koshino, and Yujiro Hayashi

  • New Dr. course member,Yogesh Gupta, joined us.

  • Fresh 5 graduate students joined us.

  • Prof. Hayashi was an invited speaker at the 14th International Conference on the Chemistry of Antibiotics and other Bioactive Compounds to be held from 13-16 October 2015 at the San Luis Resort, Galveston Island, Texas, USA.

  • Prof. Hayashi was an invited speaker at Natural Product of Gordon Research Conference at Andover in USA from July 26-31, 2015.

  • Prof. Hayashi was invited as a speaker at the seminal of the medicinal chemistry at Otsu on July 22, 2015 (Soyaku-Kagaku seminar in Japanese).

  • Our group join in the Nozoe Baseball Cup.


  • Dr. Umemiya was elected Reaxys Prize 2015 finalist

  • Dr. Umemiya leave to Phil Baran's group in TSRI

  • Mr. Umekubo won the Hiroshi-Kazuko Ogino Scholarship award

  • Pf. Negishi visited our laboratory

  • Asymmetric Organocatalyzed Epoxidation of 2-Oxoindoline-3-ylidene Acetaldehydes

    ChemCatChem, 7, 155-159 (2013)
    Takasuke Mukaiyama, Kento Ogata, Tsuyoshi Ono,and Yujiro Hayashi

  • Our laboratory invited Dr.Hiroaki Chiba as a new assistant professer"

  • Our research was selected for "25 Most Accessed Articles from Chemistry-A European Journal"


  • Hayashi is invited to 4th RSC / SCI symposium on Challenges in Catalysis for Pharmaceuticals and Fine Chemicals Burlington House, London in November 5, 2014

  • Nef reaction with molecular oxygen in absence of metal additives and its mechanistic insight

    Chem. Eur. J., 20,15753-15759 (2014)
    Shigenobu Umemiya, Kentaro Nishino, Itaru Satoh, and Yujiro Hayashi

  • Asymmetric Organocatalyzed Michael Addition of Nitrometane to 2-Oxoindoline-3-ylidene acetaldehyde and Three “One-pot” Sequential Synthesis of (-)-Horsfiline and (-)-Coerulescine

    Chem. Eur. J., 20, 13583-13588 (2014)
    Takasuke Mukaiyama, Kento Ogata, Itaru Sato, and Yujiro Hayashi

  • A Theoretical and Experimental Study of the Effects of Silyl Substituents in Enantioselective Reactions Catalyzed by Diphenylprolinol Silyl Ether

    Chem. Eur. J., ASAP
    Yujiro Hayashi, Daichi Okamura, Tatsuya Yamazaki, Yasuto Ameda, Hiroaki Gotoh, Seiji Tsuzuki, Tadafumi Uchimaru, and Dieter Seebach

  • Diphenylprolinol Silyl Ether Catalyzed Asymmetric Michael Reaction of Nitroalkanes and β,β-Disubstituted α,β-Unsaturated Aldehydes for the Construction of All-Carbon Quaternary Stereogenic Centers

    Chem. Eur. J., 38, 12072-12082 (2014)
    Yujiro Hayashi, Yuya Kawamoto, Masaki Honada, Daichi Okamura, Shigenobu Umemiya, Yuka Noguchi, Takasuke Mukaiyama, and Itaru Sato

  • Asymmetric Aldol Reaction of Formaldehyde Catalyzed by Diarylprolinol

    Chem. Lett., 43, 556-558(2014)
    Yusuke Yasui, Meryem Benohoud, Itaru Sato, and Yujiro Hayashi
    Abstracted in SYNFACTS 2014, 10(4), 0430

  • Solvent-mediated Tuning of the Regioselectivity of Intramolecular Diaryl Ether Formation: Total Synthesis of (+)-Aspercyclide C

    Chem. Lett., 43, 349-351(2014)
    Tatsuya Yoshino, Shuji Yamashita, Itaru Sato, Yujiro Hayashi, and Masahiro Hirama

  • Organocatalyst-Mediated Dehydrogenation of Aldehydes to α,β-Unsaturated Aldehydes, and Oxidative and Enantioselective Reaction of Aldehydes and Nitromethane Catalyzed by Diphenylprolinol Silyl Ether

    Adv. Synth. Catal., 355, 3661-3669 (2013)
    Yujiro Hayashi, Takahiko Itoh, and Hayato Ishikawa

  • One-Pot Synthesis of (-)-Oseltamivir and Mechanistic Insights into the Organocatalyzed Michael Reaction

    Chem. Eur. J., 19, 17789-17800 (2013)
    Takasuke Mukaiyama, Hayato Ishikawa, Hiroyuki Koshino ,and Yujiro Hayashi

  • Remote 1,6-Stereocontrol by Iminium-mediated Organocatalytic Events

    ChemCatChem, 5, 3499-3501 (2013)
    Martin. J. Lear ,and Yujiro Hayashi

  • Asymmetric Formal [3 + 2] Cycloaddition Reaction of Succinaldehyde via Diarylprolinol-mediated Domino Aldol-Acetalization Reaction for the Construction of Tetrahydrofuran

    Chem. Lett., 42,1294-1296 (2013).
    Yujiro Hayashi, Kentaro Nishino, and Itaru Sato

  • Diarylprolinol in an Asymmetric, Direct Cross-Aldol Reaction with Alkynyl Aldehydes

    ChemCatChem, 5, 2887-2892 (2013)
    Yujiro Hayashi, Masahiro Kojima, Yusuke Yasui, Yuta Kanda, Takasuke Mukaiyama, Hiroki Shomura, Daichi Nakamura, Leni Ritmaleni, and Itaru Sato

  • Asymmetric Aldol Reaction of Glyoxal Catalyzed by Diarylprolinol

    ChemCatChem, 5, 2883-2885 (2013)
    Yujiro Hayashi, and Masahiro Kojima

  • Stoichiometric Reactions of Enamines Derived from Diphenylprolinol Silyl Ethers with Nitro Olefins and Lessons for the Corresponding Organocatalytic Conversions ? a Survey

    Helv. Chim. Acta, 96, 799-852 (2013)
    Dieter Seebach, Xiaoyu Sun, Marc-Olivier Ebert, W. Bernd Schweizer, Nirupam Purkayastha, Albert K. Beck, Jorg Duschmale, Helma Wennemers, Takasuke Mukaiyama, Meryem Benohoud, Yujiro Hayashi and Markus Reiher

  • Asymmetric Mannich Reaction of α-Keto Imines Catalyzed by Diarylprolinol Silyl Ether

    Chem. Eur. J., 19, 7678-7681 (2013)
    Yujiro Hayashi, Daisuke Sakamoto, Hiroki Shomura and Daisuke Hashizume

  • Pot Economy in the Synthesis of Prostaglandin A1 and E1 Methyl Esters

    Angew. Chem., Int. Ed., 52, 3450-3452 (2013)
    Yujiro Hayashi and Shigenobu Umemiya

  • Concise Synthesis of the Tetracyclic Framework of Azadiradione: Tandem Radical Cyclization

    Chem. Lett., 42, 220-221 (2013)
    Shuji Yamashita, Akito Naruko, Takahiro Yamada, Yujiro Hayashi, Masahiro Hirama

  • Stereoselective synthesis of zoanthenol ABC-ring by radical strategy

    Tetrahedron Letters, 54, 1389 (2013)
    Shuji Yamashita, Naoki Suda, Yujiro Hayashi, Masahiro Hirama

  • Remote C-H bond functionalization of androstane C-ring: C12-amination

    Tetrahedron Letters, 54, 1307 (2013)
    Shuji Yamashita, Masafumi Himuro, Yujiro Hayashi, Masahiro Hirama

  • Organocatalytic 1,4-Addition Reaction of α,β-γ,δ-Diunsaturated Aldehyde versus 1,6-Addition Reaction

    ChemCatChem, 7, 959 (2012)
    Yujiro Hayashi, Daichi Okamura, Shigenobu Umemiya, and Tadafumi Uchimaru

  • Prof. Hayashi was awarded Novartis Chemistry Lectureship.

    Chem. & Eng. News, Sep. 5, 2011.
    Angew. Chem., Int. Ed., 51, 2809 (2012)

  • Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

    Chem. Commun.,48, 4570 (2012)
    Yujiro Hayashi, Yusuke Yasui, Masahiro Kojima, Tsuyoshi Kawamura and Hayato Ishikawa

  • High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (-)-Oseltamivir by Three “One-Pot” Operations

    Most cited paper published in Angew. Chem. Int. Ed. from 2009 to 2010.
    Rank 4th

  • Prof. Hayashi was awarded Inoue Prize for Science

  • Prof. Hayashi was awarded the Japanese Society for Process Chemistry Award 2011 for Excellence.

  • Prof. Hayashi is an invited speaker at AIMECS11, Tokyo, on November 30 th.

  • Organocatalytic, Enantioselective Intramolecular [6 + 2] Cycloaddition Reaction for the Formation of Tricyclopentanoids and Insight on Its Mechanism from a Computational Study was introduced by SYNFACTS.


  • One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by a Diphenylprolinol Silyl Ether was selected as a cover picture of Angew. Chem., Int. Ed.




  • Prof. Hayashi is an invited speaker at CATAFLU.OR Symposium, Bologna, Italy on March 24 th.

  • One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by Diphenylprolinol Silyl Ether was introduced by nature chemical biology.

  • One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by Diphenylprolinol Silyl Ether was introduced by SYNFACTS.


  • Prof. Hayashi was awarded the Chemical Society of Japan Award for Creative Work for 2010.

  • Prof. Hayashi is an invited speaker at 15th and last Oppolzer Lectures, University of Geneva, Switzerland on January 28, 2011.