The Hayashi Laboratory 東北大学林研究室

Welcome to the Home Page of the Hayashi group in the Department of chemistry, Faculty of Science, Tohoku University.

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		Updating Information May. 15. 2013 update Publication List page May. 12. 2013 update picture (Invitation lecture) page Apr. 15. 2013 update picture (Invitation lecture) page Mar. 05. 2013 update Publication List page Feb. 07. 2013 update picture (Invitation lecture) page Jan. 15. 2013 Update Picture page Jan. 01. 2013 Lecturer Shuji Yamasahita, and Lecturer Martin J. Lear entered into our lab. Dec. 03. 2012 update picture (Invitation lecture) page Nov. 17. 2012 Update Picture page Oct. 29. 2012 Update Picture page Jul.1.2012 Hayashi lab. has moved.





Reactions	Total Syntheses

Asymmetric Mannich Reaction of α-Keto Imines Catalyzed by Diarylprolinol Silyl Ether
Chem. Eur. J.,ASAP
Yujiro Hayashi, Daisuke Sakamoto, Hiroki Shomura and Daisuke Hashizume

Pot Economy in the Synthesis of Prostaglandin A1 and E1 Methyl Esters
Angew. Chem., Int. Ed., 52, 3450-3452 (2013).
Yujiro Hayashi and Shigenobu Umemiya

Concise Synthesis of the Tetracyclic Framework of Azadiradione: Tandem Radical Cyclization
Chem. Lett., 3, 220 (2013).
Shuji Yamashita, Akito Naruko, Takahiro Yamada, Yujiro Hayashi, Masahiro Hirama

Stereoselective synthesis of zoanthenol ABC-ring by radical strategy
Tetrahedron Letters, 54, 1389 (2013).
Shuji Yamashita, Naoki Suda, Yujiro Hayashi, Masahiro Hirama

Remote C-H bond functionalization of androstane C-ring: C12-amination
Tetrahedron Letters, 54, 1307 (2013).
Shuji Yamashita, Masafumi Himuro, Yujiro Hayashi, Masahiro Hirama

Organocatalytic 1,4-Addition Reaction of α,β-γ,δ-Diunsaturated Aldehyde versus 1,6-Addition Reaction
ChemCatChem, 7, 959 (2012).
Yujiro Hayashi, Daichi Okamura, Shigenobu Umemiya, and Tadafumi Uchimaru

Prof. Hayashi was awarded Novartis Chemistry Lectureship.

Chem. & Eng. News, Sep. 5, 2011.
Angew. Chem., Int. Ed., 51, 2809 (2012).
Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile
Chem. Commun.,48, 4570 (2012).
Yujiro Hayashi, Yusuke Yasui, Masahiro Kojima, Tsuyoshi Kawamura and Hayato Ishikawa

High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (-)-Oseltamivir by Three “One-Pot” Operations

Most cited paper published in Angew. Chem. Int. Ed. from 2009 to 2010.
Rank 4th

Organocatalytic, Enantioselective Intramolecular [6 + 2] Cycloaddition Reaction for the Formation of
Tricyclopentanoids and Insight on Its Mechanism from a Computational Study
J. Am. Chem. Soc., 133, 20175 (2011).
Yujiro Hayashi, Hiroaki Gotoh, Masakazu Honma, Kuppusamy Sankar, Indresh Kumar, Hayato Ishikawa, Kohzo Konno,
Hiroharu Yui, Seiji Tsuzuki, and Tadafumi Uchimaru

Synthesis of (-)-Oseltamivir by Using a Microreactor in the Curtius Rearrangement

Eur. J. Org. Chem., 6020 (2011).

Hayato Ishikawa, Bojan P. Bondzic and Yujiro Hayashi
One-Pot Synthesis of Chiral Aziridines by a Domino Reaction by Using Desulfonylative Formation on the N-Tosyl
Imine of Chloroacetaldehyde with an Asymmetric Mannich Reaction as a Key step

Chem. Eur. J., 17, 11715 (2011).
Yujiro Hayashi, Tatsuya Urushima, Daisuke Sakamoto, Kou Torii and Hayato Ishikawa

Asymmetric Mannich Reaction of Imines Derived from Aliphatic and Aromatic Aldehydes Catalyzed by Diarylprolinol　Silyl Ether

Chem. Eur. J., 17, 8273 (2011).
Tatsuya Urushima, Hayato Ishikawa and Yujiro Hayashi

Organocatalyzed Michael Addition of Aldehydes to Nitro Alkenes - Generally Accepted Mechanism Revisited and

Revised.
Helvetica Chemica Acta, 94, 719 (2011).
Krystyna Patora-Komisarska, Meryem Benohoud, Hayato Ishikawa, Dieter Seebach and Yujiro Hayashi

One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by a Diphenylprolinol Silyl Ether was selected as a cover picture of Angew. Chem., Int. Ed.

Asymmetric One-Pot Four-Component Coupling Reaction: Synthesis of Substituted Tetrahydropyrans Catalyzed by Diphenylprolinol Silyl Ether

Angew. Chem., Int. Ed., 50, 3774 (2011).

Hayato Ishikawa, Satoshi Sawano, Yusuke Yasui, Yusuke Shibata and Yujiro Hayashi

Prof. Hayashi is an invited speaker at CATAFLU.OR Symposium, Bologna, Italy on March 24 th.
One-Pot Synthesis of Chiral α-Substituted β,γ-Epoxy Aldehyde Derivatives through an Asymmetric Aldol Reaction of Chloroacetaldehyde
Angew. Chem., Int. Ed., 50, 2804 (2011).

Yujiro Hayashi, Yusuke Yasui, Tsuyoshi Kawamura, Masahiro Kojima and Hayato Ishikawa

Diarylprolinol in the Direct Asymmetric Aldol Reaction of Trifluoromethylacetaldehyde Ethyl Hemiacetal with aldehyde

Synlett, 485, (2011).

Yujiro Hayashi, Yusuke Yasui, Tsuyoshi Kawamura, Masahiro Kojima and Hayato Ishikawa
One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by a Diphenylprolinol Silyl Ether
Angew. Chem., Int. Ed., 50, 2824 (2011).
Hayato Ishikawa, Masakazu Honma, and Yujiro Hayashi

Very Important Paper
One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by Diphenylprolinol Silyl Ether was introduced by nature chemical biology.